This Study Aims to Evaluate the Effect of Rinsing Off or Blot-drying Silver Fluoride on the Retention of Subsequently-applied Resin- and Glass Ionomer-based Fissure Sealants in Permanent Molars Affected by Molar-Incisor Hypomineralization.

Summary

The aim of this study is three-fold: 1. To evaluate the clinical performance of glass ionomer fissure sealants and resin fissure sealants when placed immediately after or one week following the application of silver fluoride on permanent molars affected by Molar-Incisor Hypomineralization in high caries-risk children. 2. To compare the effects of rinsing off the silver fluoride or not rinsing it off (blot-drying with cotton pellet) on sealant retention when the sealant is placed immediately after silver fluoride application, and 3. To measure the desensitizing effect of fissure sealant application following silver fluoride treatment on hypersensitive MIH molars.

Conditions

• Molar Incisor Hypomineralisation
• Children
• Dental Caries

Interventions

DEVICE

Immediate restoration (resin- based) after blot-drying silver fluoride application

Blot-drying silver fluoride with cotton pellet followed by resin-based fissure sealant

DEVICE

Immediate restoration (GI- based) after blot-drying silver fluoride application

Blot-drying silver fluoride with cotton pellet followed by glass ionomer-based fissure sealant

DEVICE

Immediate restoration (Resin based) after rinsing silver fluoride application

Rinsing silver fluoride off followed by resin-based fissure sealant

DEVICE

Immediate restoration (GIC) after rinsing silver fluoride application

Rinsing silver fluoride off and blot-drying of fissures followed by glass ionomer-based fissure sealant

DEVICE

Resin based fissure sealant restoration one week after silver fluoride (AgF) application

Resin based fissure sealant restoration one week after silver fluoride (AgF) application

DEVICE

GI- based fissure sealant restoration one week after silver fluoride (AgF) application

GI- based fissure sealant restoration one week after silver fluoride (AgF) application

Sponsors & Collaborators

• Hacettepe University

  lead OTHER

Principal Investigators

• Elif Ballikaya, DDS, PhD · Hacettepe University

• Zafer Cehreli, DDS, PhD · Hacettepe University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

6 Years

Max Age

14 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-07-31

Primary Completion

2025-10-30

Completion

2026-10-30

Countries

• Turkey (Türkiye)

Study Locations