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Impact of Pretreatment Emotional Distress on Survival and the Predictive Role of Peripheral Biomarkers in Immunotherapy Response Among Gastroesophageal and Lung Cancer Patients

NCT06629714 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 196

Last updated 2026-01-13

No results posted yet for this study

Summary

This is the prospective, observational cohort study to explore the impact of pretreatment emotional distress on survival and the predictive role of peripheral blood metabolic and inflammatory markers in immunotherapy response among treatment-naïve, advanced and inoperable Gastroesophageal Cancer (GEC) and non-small-cell lung cancer (NSCLC).

Conditions

  • Non Small Cell Lung Cancer
  • Immune Checkpoint Inhibitors
  • Inflammation
  • Cancer, Treatment-Related
  • Emotional Distress
  • Gastroesophageal Cancer (GC)
  • Biomarkers / Blood
  • Progression-free Survival, PFS

Interventions

OTHER

Exposure: emotional distress status

The assessment of depressive and anxiety symptoms was conducted using Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder Assessment 7 (GAD-7). Patients with a sum score of PHQ-9 and GAD-7 ≥ 10 were categorized as the stressed group.

Sponsors & Collaborators

  • Anhui Medical University

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-10-16
Primary Completion
2025-04-20
Completion
2025-04-20

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06629714 on ClinicalTrials.gov