Losartan and Emotional Learning
NCT06628154 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 60
Last updated 2024-10-04
Summary
This study explores the effects of single-dose losartan (50mg) versus placebo on emotional processing in healthy volunteers.
Conditions
- Emotional Processing
Interventions
- DRUG
-
Losartan potassium 50mg
Single dose losartan (50 mg, weight-adjusted), encapsulated identically to placebo
- OTHER
-
Placebo
Single tablet encapsulated identically to losartan
Sponsors & Collaborators
-
Oxford Health Biomedical Research Centre (OH BRC) support scheme
collaborator UNKNOWN -
University of Oxford
lead OTHER
Principal Investigators
-
Andrea Reinecke, PhD · University of Oxford
Study Design
- Allocation
- RANDOMIZED
- Purpose
- BASIC_SCIENCE
- Masking
- TRIPLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 50 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2024-08-14
- Primary Completion
- 2025-07-31
- Completion
- 2025-07-31
Countries
- United Kingdom
Study Locations
More Related Trials
-
Characterizing and Predicting Drug Effects on Cognition
NCT01889602 ·Status: COMPLETED ·Phase: PHASE4
-
The Impact of Lorazepam on Cognition in APOE e4 Carriers
NCT00586430 ·Status: COMPLETED ·Phase: NA
-
Effect of Treatment With EGb 761(r) on Blood Markers of Inflammation and Oxidative Stress in Patients With MCI
NCT05594355 ·Status: UNKNOWN ·Phase: PHASE4
-
Efficacy and Safety of Lornoxicam in Patients With Mild to Moderate Probable Alzheimer´s Disease.
NCT01117948 ·Status: TERMINATED ·Phase: PHASE2
-
Neuromodulation and Language Acquisition (Stage Ib)
NCT00102856 ·Status: SUSPENDED ·Phase: PHASE4
-
Acute Effect of Lorazepam on Brain Activity Measured by Magnetoencephalograpy (MEG) and Electroencephalography (EEG)
NCT01272778 ·Status: UNKNOWN ·Phase: NA
-
Effect of Rasagiline on BIA 9-1067 Pharmacokinetics
NCT01532141 ·Status: COMPLETED ·Phase: PHASE1
-
Safety and Efficacy Study of Ladostigil in Mild to Moderate Probable Alzheimer's Disease
NCT01354691 ·Status: COMPLETED ·Phase: PHASE2
-
Study Evaluating the Safety of Lecozotan SR in Healthy Young and Elderly Subjects
NCT00366483 ·Status: COMPLETED ·Phase: PHASE1
-
Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia
NCT01937013 ·Status: COMPLETED ·Phase: PHASE2
-
A Sedation/Cognition/EEG Study Using AZD6280 and Comparator
NCT00750802 ·Status: COMPLETED ·Phase: PHASE1
-
16w Interventional Study on Titration and Dose/Efficacy Assessment of Exelon in Chinese Alzheimer's Disease Patients
NCT01948791 ·Status: COMPLETED ·Phase: PHASE4
-
Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial
NCT06580002 ·Status: RECRUITING ·Phase: PHASE2
-
Rosiglitazone Effects on Cognition for Adults in Later Life
NCT00242593 ·Status: UNKNOWN ·Phase: PHASE2
-
The Cognitive Effects of Lorazepam in Healthy Older Individuals With TOMM40 Variable-length Polymorphisms
NCT01780519 ·Status: COMPLETED ·Phase: PHASE1
-
Reversing Corticosteroid Induced Memory Impairment
NCT01142310 ·Status: COMPLETED ·Phase: PHASE4
-
Influence of Triflusal on Cognitive Functions in Healthy Subjects
NCT02321852 ·Status: COMPLETED ·Phase: PHASE2
-
Effect of a Plant Based Nootropic on Perceptual Decision Making.
NCT06689644 ·Status: COMPLETED ·Phase: NA
-
Efficacy and Safety of Eriobotyra Japonica Lindley Extract on Improvement of Cognitive Function
NCT01734200 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
A 3 Year Study to Evaluate the Safety and Efficacy of Low Dose Ladostigil in Patients With Mild Cognitive Impairment
NCT01429623 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Seltorexant in Participants With Probable Alzheimer's Disease
NCT05307692 ·Status: COMPLETED ·Phase: PHASE2
-
Effects of Vortioxetine (Lu AA21004) on the Concentrations of Selected Neurotransmitters in Healthy Male Adults
NCT01299805 ·Status: COMPLETED ·Phase: PHASE1
-
INTERCEPTOR Project: From MCI to Dementia
NCT03834402 ·Status: COMPLETED
-
Synaptic Plasticity and Cognitive Function in RASopathies
NCT03504501 ·Status: TERMINATED ·Phase: PHASE2
-
Network-Level Mechanisms for Preclinical Alzheimer's Disease Development
NCT03461861 ·Status: COMPLETED ·Phase: PHASE2