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Steroid Versus Mitomycin-C Use in Pediatric Benign Recurrent Esophageal Stricture

NCT06626802 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2024-10-04

No results posted yet for this study

Summary

To compare the efficacy of steroid injection versus topical mitomycin-C in the treatment of pediatric benign recurrent esophageal strictures. The rationale for this study is to compare the two therapeutic options in order to measure their effectiveness, in terms of improvement of Dysphagia Severity Score (DSS).

Conditions

  • Esophageal Stricture

Interventions

PROCEDURE

Balloon Dilation + Topical Mitomycin

Patients with recurrent esophageal strictures in Group A will undergo endoscopy and balloon dilation with a CRE balloon, followed by injection Mitomycin applied topically at stricture site (post dilation)

PROCEDURE

Balloon Dilation + Injection Triamcinolone

Patients with recurrent esophageal strictures in Group B will undergo endoscopy and balloon dilation with a CRE balloon, followed by injection Triamcinolone, injected with a sclerotherapy injector, at stricture site (post dilation)

Sponsors & Collaborators

  • Children Hospital and Institute of Child Health, Lahore

    collaborator OTHER

  • King Edward Medical University

    lead OTHER

Principal Investigators

  • Tehreem Fatima, FCPS, MRCPCH · University of Child Health Sciences, Lahore

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Max Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-01
Primary Completion
2024-06-30
Completion
2024-06-30

Countries

  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06626802 on ClinicalTrials.gov