Trial Outcomes & Findings for Efficacy and Mechanism of Fecal Microbiota Transplantation of the Bai Ethnicity in the Treatment of UC (NCT NCT06591013)

Results Overview

total Mayo score of ≤2 points with no individual sub-score \>1 point, and at least a 1 point reduction from baseline in the endoscopy sub-score (MES).

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

102 participants

Primary outcome timeframe

12 weeks after fecal microbiota transplantation

Results posted on

2026-06-30

Participant Flow

Participant milestones

Participant milestones
Measure	the Bai Nationality-UC Ulcerative colitis subjects will be treated with bacterial solution from the Bai nationality by colonoscope	the Han Nationality-UC Ulcerative colitis subjects will be treated with bacterial solution from the Han nationality by colonoscope
Overall Study STARTED	41	48
Overall Study COMPLETED	30	31
Overall Study NOT COMPLETED	11	17

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	the Bai Nationality-UC n=41 Participants Ulcerative colitis subjects will be treated with bacterial solution from the Bai nationality by colonoscope	the Han Nationality-UC n=48 Participants Ulcerative colitis subjects will be treated with bacterial solution from the Han nationality by colonoscope	Total n=89 Participants Total of all reporting groups
Age, Continuous	45 years n=41 Participants	44.73 years n=48 Participants	44.85 years n=89 Participants
Sex: Female, Male Female	13 Participants n=41 Participants	20 Participants n=48 Participants	33 Participants n=89 Participants
Sex: Female, Male Male	28 Participants n=41 Participants	28 Participants n=48 Participants	56 Participants n=89 Participants
Race and Ethnicity Not Collected	—	—	0 Participants Race and Ethnicity were not collected from any participant.

PRIMARY outcome

Timeframe: 12 weeks after fecal microbiota transplantation

total Mayo score of ≤2 points with no individual sub-score \>1 point, and at least a 1 point reduction from baseline in the endoscopy sub-score (MES).

Outcome measures

Outcome measures
Measure	the Bai Nationality-UC n=30 Participants Ulcerative colitis subjects will be treated with bacterial solution from the Bai nationality by colonoscope	the Han Nationality-UC n=31 Participants Ulcerative colitis subjects will be treated with bacterial solution from the Han nationality by colonoscope
a Composite of Steroid-free Clinical Remission Together With Endoscopic Remission or Response	24 Participants	16 Participants

SECONDARY outcome

Timeframe: 8 to 12 weeks after fecal microbiota transplantation

total Mayo score of ≤2 points with no individual sub-score \>1 point

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 8 to 12 weeks after fecal microbiota transplantation

reduction of 3 points or more on the Mayo score, a 50% or greater reduction from baseline in combined rectal bleeding plus stool frequency Mayo sub-scores, or both

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 8 to 12 weeks after fecal microbiota transplantation

Mayo endoscopy sub-score of 1 or less, with a reduction of at least 1 point from baseline