A Study to Evaluate the Effects of Itraconazole on MK-1708 in Healthy Participants (MK-1708-003)
NCT06586606 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 12
Last updated 2024-12-18
Summary
The goal of the study is to see what happens to levels of MK-1708 a person's body over time. Researchers will compare what happens to MK-1708 in the body when it is given with or without a medicine called itraconazole.
Conditions
Interventions
- DRUG
-
MK-1708
Oral administration
- DRUG
-
Itraconazole
Oral administration
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Medical Director · Merck Sharp & Dohme LLC
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Max Age
- 50 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2024-10-03
- Primary Completion
- 2024-12-10
- Completion
- 2024-12-10
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Safety, Tolerability and Efficacy Study to Evaluate Subjects With Mild Cognitive Impairment
NCT00422981 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of MK-1167 in Participants With Alzheimer's Disease Dementia Taking Stable Donepezil Treatment (MK-1167-007)
NCT06285240 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate the Effects of MK-0249 and an Alzheimer's Disease Medication on Cognitive Function in Adults With Alzheimer's Disease (MK-0249-023)
NCT00874939 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of MK-2214 in Adults With Mild Cognitive Impairment or Mild-to-Moderate Alzheimer's Disease (MK-2214-002)
NCT05466422 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of SHR-1707 With Mild Cognitive Impairment Due to Alzheimer's Disease or Mild Alzheimer's Disease
NCT05681819 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS-MAPTRx in Patients With Mild Alzheimer's Disease
NCT03186989 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase I Study for Safety and Tolerability of AL002.
NCT03635047 ·Status: COMPLETED ·Phase: PHASE1
-
Repurposing Nucleoside Reverse Transcriptase Inhibitors for Treatment of AD
NCT04500847 ·Status: RECRUITING ·Phase: PHASE1
-
Study of MK0677 for the Treatment of Alzheimer's Disease (0677-030)(COMPLETED)
NCT00074529 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Efficacy Study Evaluating TRx0237 in Subjects With Mild Alzheimer's Disease
NCT01689233 ·Status: COMPLETED ·Phase: PHASE3
-
Study of ITI-007 in Healthy Geriatric Volunteers and in Geriatric Patients With Dementia
NCT02078310 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Trial of SHR-1707 in Healthy Young Adult and Elderly Subjects
NCT04745104 ·Status: COMPLETED ·Phase: PHASE1
-
Multiple Ascending Dose Study of TC-5619 in Healthy Elderly Subjects and Subjects With Alzheimer's Disease
NCT01254448 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of SHR-1707 in Healthy Young Adult and Elderly Subjects
NCT04973189 ·Status: COMPLETED ·Phase: PHASE1
-
Multiple Dose Trial of MK-4334 in Participants With Alzheimer's Clinical Syndrome (MK-4334-005)
NCT03740178 ·Status: WITHDRAWN ·Phase: PHASE1
-
A Study of E2814 With Concurrent Lecanemab Treatment in Participants With Early Alzheimer's Disease
NCT06602258 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Safety and Pharmacodynamics of SHR-1707 in Alzheimer's Disease Patients
NCT06199037 ·Status: TERMINATED ·Phase: PHASE2
-
Study of IGC-AD1 in Subjects With Dementia Due to Alzheimer's Disease
NCT04749563 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase I Clinical Study on the Safety and Pharmacokinetics of [18F]Florbetazine Injection
NCT06593626 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase Ia/Ib, First-in-human (FIH) Study for Safety, Tolerability, Pharmacokinetics (PK), and Clinical Activity Evaluation of ADEL-Y01
NCT06247345 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of ONO-2020 in Participants With Mild to Moderate Alzheimer's Disease
NCT06881836 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Phase IIa Multi-Center Study of 18F-FDG PET, Safety, and Tolerability of AZD0530 in Mild Alzheimer's Disease
NCT02167256 ·Status: COMPLETED ·Phase: PHASE2
-
A Clinical Trial to Compare Forms of MK-1167 in Healthy People (MK-1167-011)
NCT07334860 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A First Time in Human Study of SNP318 as a Treatment for Neurodegenerative Diseases Including Alzheimer's Disease
NCT05792163 ·Status: COMPLETED ·Phase: PHASE1
-
Single and Repeated Dosing Study to Assess the Safety and the Concentration-time Profile of SAR228810 in Alzheimer's Patients
NCT01485302 ·Status: COMPLETED ·Phase: PHASE1