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Next-Generation Endometriosis Diagnostics Through Comprehensive Multi-Dimensional Analysis

NCT06572852 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 530

Last updated 2025-10-07

No results posted yet for this study

Summary

This study is a multicentric, observational, case-control, non-profit with additional procedures. It aims to deepen the understanding of the chronic gynecological conditions of endometriosis and adenomyosis, which significantly impact women's reproductive health. Its purpose is to improve early diagnosis and personalized treatment of these conditions using a multi-omic approach, that integrates genetic, epigenetic, imaging, and endometrial receptivity data. The goal is also to refine image-based predictions through recent advancements in artificial intelligence and to study uterine extracellular vesicles to assess fertility non-invasively.

The study targets patients with endometriosis and/or adenomyosis and involves women seeking fertility treatments at assisted reproduction centers, who will serve as a control population.

The study comprises both prospective and retrospective components. The prospective recruitment involves the collection of blood and uterine fluid samples, while the retrospective element utilizes pre-existing biobank samples for comprehensive genetic and epigenetic analysis.

Conditions

  • Endometriosis
  • Adenomyosis

Interventions

OTHER

No intervention

No intervention

Sponsors & Collaborators

  • AUO Renato Dulbecco

    collaborator UNKNOWN

  • IRCCS San Raffaele

    lead OTHER

Principal Investigators

  • MASSIMO CANDIANI · IRCCS San Raffaele

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-11-07
Primary Completion
2026-02-28
Completion
2026-08-30

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06572852 on ClinicalTrials.gov