Time for a Diagnostic Paradigm Shift From STEMI/NSTEMI to OMI/NOMI

Summary

The investigators hypothesize that occlusion myocardial infarction(MI)/non-occlusion MI approach to MI treatment will better predict acute coronary occlusion on coronary angiography, better limit infarct size, better preserve left ventricular function and result in lower long-term adverse cardiac events (all cause mortality, all cause rehospitalization) compared to standard ST-elevation/non-ST-elevation MI paradigm.

Conditions

• Myocardial Infarction
• Myocardial Ischemia
• Acute Coronary Syndrome
• Diagnosis
• Morality

Interventions

PROCEDURE

Early intervention for OMI

Early PCI for OMI (+) STEMI (-) patients

PROCEDURE

Standard early intervention for STEMI

Early PCI for OMI (+) and STEMI (+) patients

PROCEDURE

Standard delayed intervention for NSTEMI

Medical stabilization and then PCI for OMI (-) and STEMI (-) patients

Sponsors & Collaborators

• Ankara Etlik City Hospital

  collaborator OTHER_GOV

• Antalya City Hospital

  collaborator UNKNOWN

• Bağcılar Training and Research Hospital

  collaborator UNKNOWN

• Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital

  collaborator OTHER

• Ataturk University

  collaborator OTHER

• Eskisehir City Hospital

  collaborator OTHER

• Kartal Kosuyolu High Speciality Training and Research Hospital

  collaborator OTHER_GOV

• Marmara University Pendik Training and Research Hospital

  collaborator OTHER

• Istanbul Mehmet Akif Ersoy Educational and Training Hospital

  collaborator OTHER_GOV

• Muğla Sıtkı Koçman University

  collaborator OTHER

• Necmettin Erbakan University

  collaborator OTHER

• Eskisehir Osmangazi University

  collaborator OTHER

• Sirnak State Hospital

  collaborator OTHER_GOV

• Tokat Gaziosmanpasa University

  collaborator OTHER

• Van Training and Research Hospital

  collaborator OTHER_GOV

• Yuzuncu Yıl University

  collaborator OTHER

• Kutahya Health Sciences University

  collaborator OTHER

• Başakşehir Çam & Sakura City Hospital

  lead OTHER_GOV

Principal Investigators

• Emre K Aslanger, Prof · Basaksehir Pine and Sakura City Hospital

Study Design

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

99 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-10-01

Primary Completion

2025-09-01

Completion

2026-09-01

Countries

• Turkey (Türkiye)

Study Locations