Trial Outcomes & Findings for Social Media as a Risk Tool for HIV Prevention Needs (NCT NCT06566417)

NCT ID: NCT06566417

Last Updated: 2026-08-31

Results Overview

The investigators will compare the above-noted measure datasets with the Wand risk score as assessed in the study participants at the time of SMS/social media data collection. The Wand risk score is an empirically validated HIV prediction tool designed to estimate the probability of HIV acquisition in women. It calculates a total score (max 50 pts): age \<20 years (11 pts), 20-24 years (10 pts), 25-29 years (6 pts), 30+ years (0 pts); marital status of single/not cohabitating (13 pts), married/cohabitating (0 pts); # sexual partners in last 3 months of 3 or more (5 pts), \<3 (0 pts); age at sexual debut of \<16 years (3 pts), 16+ years (0 pts); parity (# of births) of 0-1 births (10 pts), 2 births (8 pts), 3+ births (0 pts); ever diagnosed with an STI as yes (4 pts), no (0 pts); and use of injectable contraception as yes (4 pts), no (0 pts). A higher score denotes a higher HIV risk. The total possible range is 0-50.

Recruitment status

COMPLETED

Target enrollment

400 participants

Primary outcome timeframe

6 months of data given at one time

Results posted on

2026-08-31

Participant Flow

Note: Ineligible participants provided baseline demographic/behavioral information only under verbal consent (according to IRB approval).

Participant milestones

Participant milestones
Measure
Young Women
young women (ages 18-24) in Kisumu, Kenya who used WhatsApp and were willing to share their messages, and who could understand Swahili, DhoLuo, and/or English (the most spoken languages in the region)
Overall Study
STARTED
400
Overall Study
COMPLETED
400
Overall Study
NOT COMPLETED
0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Social Media as a Risk Tool for HIV Prevention Needs

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
Young Women
n=400 Participants
young women (ages 18-24) in Kisumu, Kenya who used WhatsApp and were willing to share their messages, and who could understand Swahili, DhoLuo, and/or English (the most spoken languages in the region
Age, Categorical
<=18 years
0 Participants
n=14 Participants
Age, Categorical
Between 18 and 65 years
400 Participants
n=14 Participants
Age, Categorical
>=65 years
0 Participants
n=14 Participants
Age, Continuous
22.0 years
STANDARD_DEVIATION 1.6 • n=14 Participants
Sex: Female, Male
Female
400 Participants
n=14 Participants
Sex: Female, Male
Male
0 Participants
n=14 Participants
Race (NIH/OMB)
American Indian or Alaska Native
0 Participants
n=14 Participants
Race (NIH/OMB)
Asian
0 Participants
n=14 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
0 Participants
n=14 Participants
Race (NIH/OMB)
Black or African American
400 Participants
n=14 Participants
Race (NIH/OMB)
White
0 Participants
n=14 Participants
Race (NIH/OMB)
More than one race
0 Participants
n=14 Participants
Race (NIH/OMB)
Unknown or Not Reported
0 Participants
n=14 Participants
Region of Enrollment
Kenya
400 Participants
n=14 Participants

PRIMARY outcome

Timeframe: 6 months of data given at one time

The investigators will compare the above-noted measure datasets with the Wand risk score as assessed in the study participants at the time of SMS/social media data collection. The Wand risk score is an empirically validated HIV prediction tool designed to estimate the probability of HIV acquisition in women. It calculates a total score (max 50 pts): age \<20 years (11 pts), 20-24 years (10 pts), 25-29 years (6 pts), 30+ years (0 pts); marital status of single/not cohabitating (13 pts), married/cohabitating (0 pts); # sexual partners in last 3 months of 3 or more (5 pts), \<3 (0 pts); age at sexual debut of \<16 years (3 pts), 16+ years (0 pts); parity (# of births) of 0-1 births (10 pts), 2 births (8 pts), 3+ births (0 pts); ever diagnosed with an STI as yes (4 pts), no (0 pts); and use of injectable contraception as yes (4 pts), no (0 pts). A higher score denotes a higher HIV risk. The total possible range is 0-50.

Outcome measures

Outcome measures
Measure
Young Women
n=400 Participants
Young women (ages 18-24) in Kisumu, Kenya who use WhatsApp
Association of Artificial Intelligence Measure Datasets With the Wand Risk Score
32.8 Wand risk score
Standard Deviation 6.4

PRIMARY outcome

Timeframe: 6 months

Analysts will examine 6 months of SMS/social media message content from each of the 400 study participants using three computational linguistic methods: 1) sentiment, valence, and arousal analysis; 2) topic modeling; 3) simple textual counts. Analysts will also perform network analysis with up to 20 contacts from each participant to understand how often and with which parties the participant communicates most frequently. These networks will be examined temporally to see if any of the connections have grown or weakened over time. The VOICE risk score (modified to not use biological markers) is a measure of behavioral and demographic factors to determine HIV risk: \<25 y/o (2 pts), unmarried or not living with a partner (2 pts), primary partner has other partners (2 pts), partner does not provide financial support (1 pt), alcohol use in the last 3 months (1 pt). A higher score denotes a greater HIV risk. The total possible range is 0-8.

Outcome measures

Outcome measures
Measure
Young Women
n=400 Participants
Young women (ages 18-24) in Kisumu, Kenya who use WhatsApp
Association of Artificial Intelligence Measure Datasets With the VOICE Risk Score
5.7 VOICE risk score
Standard Deviation 1.4

Adverse Events

Young Women

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Jessica Haberer

Massachusetts General Hospital

Phone: 617-724-0351

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place