MedTrace Logo

UCAN CAN-DU: Canada-Netherlands Personalized Medicine Network in Childhood Arthritis and Rheumatic Disease

NCT06560606 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 4100

Last updated 2024-08-19

No results posted yet for this study

Summary

Childhood arthritis is a chronic disabling disease. New medications called biologic therapies are now available to treat arthritis that target key biologic molecules that cause inflammation. Biologic therapies, while very effective in treating arthritis in children, may have serious side effects including infections and potentially cancers, and are very expensive and doctors don't know, which one to choose for which child. The investigators will develop tests that enable them to learn about the biology of each child's arthritis and be able to predict when and which biologic therapy to start and when to stop.

Conditions

  • Juvenile Idiopathic Arthritis

Sponsors & Collaborators

  • Canadian Institutes of Health Research (CIHR)

    collaborator OTHER_GOV

  • Genome Canada

    collaborator OTHER

  • Genome Alberta

    collaborator OTHER

  • The Arthritis Society, Canada

    collaborator OTHER

  • ReumaNederland

    collaborator UNKNOWN

  • ZonMw: The Netherlands Organisation for Health Research and Development

    collaborator OTHER

  • Alberta Children's Hospital

    collaborator OTHER

  • Ontario Genomics

    collaborator UNKNOWN

  • The Hospital for Sick Children

    lead OTHER

Principal Investigators

  • Rae SM Yeung, MD, PhD, FRCPC · The Hospital for Sick Children (SickKids), University of Toronto

  • Nico Wulffraat, MD, PhD · Wilhelmina Children's Hospital, University Medical Center Utrecht

  • Susa Benseler, MD, PhD · Alberta Children's Hospital and Cumming School of Medicine, University of Calgary

  • Joost Swart, MD, PhD · Wilhelmina Children's Hospital, University Medical Center Utrecht

  • Bas Vastert, MD, PhD · Wilhelmina Children's Hospital, University Medical Center Utrecht

Eligibility

Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-08-24
Primary Completion
2025-03-30
Completion
2027-03-30

Countries

  • Canada
  • Netherlands

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06560606 on ClinicalTrials.gov