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Anastomotic Leaks in Esophageal Squamous Cell Carcinoma Patients After Trimodal Therapy

NCT06556355 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 218

Last updated 2024-08-16

No results posted yet for this study

Summary

To investigate the clinical factors and preoperative treatment to the future anastomotic location of cervical esophagus that were correlated with anastomotic leaks in esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoradiation and McKeown esophagectomy and to explore the prognosis of anastomotic leak.

Conditions

  • Anastomotic Leak Esophagus

Interventions

OTHER

neoadjuvant chemoradiation and McKeown esophagectomy

Treatment protocol: 1. All patients were irradiated a total prescribed dose of 40-50.4 Gy in 20-28 fractions by a 6-8 MV photons linear accelerator with the intensity-modulated radiotherapy or volumetric modulated arc therapy technique. 2. Concurrent chemotherapy was cisplatin-based. 3. McKeown esophagectomy (three incision) consisted of thoracic esophageal mobilization with lymphadenectomy, abdominal exploration and stomach mobilization with lymphadenectomy, and subsequently left cervical incision for anastomosis. The lymphadenectomy was total two-field (thoracic + abdomen).

Sponsors & Collaborators

  • Chinese Institute of Food Science and Technology

    collaborator UNKNOWN

  • Qiaoqiao Li

    lead OTHER

Principal Investigators

  • Qiaoqiao Li · Sun Yat-sen University Cancer Center, Guangzhou, China

  • Chen Yang · Sun Yat-sen University Cancer Center, Guangzhou, China

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-11-01
Primary Completion
2023-09-15
Completion
2023-09-15

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06556355 on ClinicalTrials.gov