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Breath Analysis for the Detection of Invasive Fungal Infections

NCT06537726 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2025-04-10

No results posted yet for this study

Summary

Patients with leukemia and concomitant neutropenia are at high risk of developing invasive fungal infections (IFI) that are associated with high morbidity and mortality. As these patients typically have severe thrombocytopenia, direct diagnostic sampling with invasive procedures is often not possible due to the high peri-interventional risk. Therefore, the presumptive diagnosis of IFI is primarily based on compatible lung findings on computed tomography and serologic detection of fungal cell wall components, which, however, have limited sensitivity and specificity.

With the present study, the investigators aim to determine a set of specific volatile biomarkers in leukemia patients with proven or probable IFI using secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS).

Conditions

  • Leukemia
  • Leukemia, Myeloid
  • Leukemia, Lymphoblastic
  • Neutropenia
  • Chemotherapy-induced Neutropenia
  • Invasive Fungal Infections
  • Invasive Pulmonary Aspergillosis

Interventions

DIAGNOSTIC_TEST

Secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS)

Identify volatile biomarkers of IFI by analyzing the breath metabolome of patients with proven or probable IFI according to the criteria outlined by EORTC/MSG and controls.

Sponsors & Collaborators

  • University of Zurich

    lead OTHER

Principal Investigators

  • Jeremy Deuel, PD Dr. · University of Zurich

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-08-19
Primary Completion
2027-10-31
Completion
2027-10-31

Countries

  • Switzerland

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06537726 on ClinicalTrials.gov