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The Presence of Microplastics and Nanoplastics in the Humans Ileum, Colon, and Rectum and Their Relation With Inflammatory Bowel Disease (IBD)

NCT06525558 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 102

Last updated 2025-05-02

No results posted yet for this study

Summary

Based on recent studies it is hypothesized that microplastics and nanoplastics (MNPs) are present in human's ileum, colon, and rectum and that their presence may have a correlation with Inflammatory Bowel Disease (IBD).

This study is a cross-sectional, single-center, non-profit observational study. The main objectives are to define in vitro the presence of MNPs in the humans ileum, colon, and rectum and to evaluate if there is a correlation between this presence and IBD. In vitro metabolomics and proteomics analyses of the study sample and the assessment of participants' daily plastic exposure are considered exploratory objectives. For this purpose, a total of 102 patients undergoing a surgery where intestinal resection is included, will be enrolled.

Conditions

Interventions

PROCEDURE

Intestinal resection

This study does not add additional risks for patients as the resected specimen is collected during the surgery in accordance with standard clinical practice.

Sponsors & Collaborators

  • Pierpaolo Sileri

    lead OTHER

Principal Investigators

  • Pierpaolo Sileri, Prof. · IRCCS Ospedale San Raffaele

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-30
Primary Completion
2025-09-30
Completion
2025-12-30

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06525558 on ClinicalTrials.gov