A Study of Imvotamab in Active, Refractory Idiopathic Inflammatory Myopathies
NCT06524687 · Status: TERMINATED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 2
Last updated 2025-02-11
Summary
The purpose of this study is to determine the safety and tolerability of imvotamab in patients with Moderate-Severe Idiopathic Inflammatory Myopathies who have failed prior therapies.
Participants will be given imvotamab through a vein (i.e., intravenously).
Conditions
- Idiopathic Inflammatory Myopathies
- Inflammatory Myopathies
Interventions
- DRUG
-
Imvotamab
Administered intravenously
Sponsors & Collaborators
-
IGM Biosciences, Inc.
lead INDUSTRY
Principal Investigators
-
Rebecca Kunder · IGM Biosciences
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-05-29
- Primary Completion
- 2025-01-21
- Completion
- 2025-01-21
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis
NCT07039916 ·Status: RECRUITING ·Phase: PHASE3
-
Intravenousimmunoglobulin (IVIg) for the Treatment of Inflammatory Myopathies
NCT00001261 ·Status: COMPLETED ·Phase: PHASE2
-
Alemtuzumab to Treat Sporadic Inclusion Body Myositis
NCT00079768 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of Bimagrumab/BYM338 at 52 Weeks on Physical Function, Muscle Strength, Mobility in sIBM Patients
NCT01925209 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Ublituximab in Autoantibody Positive Immune Mediated Necrotizing Myopathy
NCT07103746 ·Status: RECRUITING ·Phase: PHASE2
-
Immune Abnormalities in Sporadic Inclusion Body Myositis
NCT00030212 ·Status: COMPLETED
-
RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy
NCT06154252 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
An Extension Study of the Efficacy, Safety and Tolerability of BYM338 (Bimagrumab) in Patients With Sporadic Inclusion Body Myositis Who Previously Participated in the Core Study CBYM338B2203
NCT02573467 ·Status: COMPLETED ·Phase: PHASE3
-
In Vitro Study of the Biological and Immunological Activity of Imotopes® Candidates on Blood Cells of Patients With Stabilized NMO
NCT04629274 ·Status: COMPLETED ·Phase: NA
-
The MIGHT Trial - An Exploratory Clinical Trial of IVIG in Anti-HMGCR Immune Mediated Necrotizing Myopathy
NCT06599697 ·Status: RECRUITING ·Phase: PHASE2
-
IMPT-514 in Systemic Lupus Erythematosus, Anca-associated Vasculitis, and Idiopathic Inflammatory Myopathy
NCT06462144 ·Status: TERMINATED ·Phase: EARLY_PHASE1
-
A Study to Understand How the Study Medicine Dazukibart Works in People With Idiopathic Inflammatory Myopathies
NCT06698796 ·Status: RECRUITING ·Phase: PHASE3
-
A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)
NCT06455449 ·Status: RECRUITING ·Phase: PHASE3
-
A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy.
NCT05523167 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2/PHASE3
-
GC012F Injection in Refractory Idiopathic Inflammatory Myopathy
NCT07086404 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Arimoclomol in Sporadic Inclusion Body Myositis - Open Label Extension Trial
NCT04049097 ·Status: TERMINATED ·Phase: PHASE3
-
Safety and Efficacy of REGN2477+REGN1033 in Patients With Sporadic Inclusion Body Myositis
NCT03710941 ·Status: WITHDRAWN ·Phase: PHASE2
-
A Study of Nipocalimab in Participants With Active Idiopathic Inflammatory Myopathies
NCT05379634 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Ruxolitinib Treatment in Inclusion Body Myositis
NCT06536166 ·Status: RECRUITING ·Phase: PHASE2
-
Belimumab in Idiopathic Inflammatory Myositis
NCT02347891 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Allogeneic Mitochondria (PN-101) Transplantation for Refractory Polymyositis or Dermatomyositis
NCT04976140 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Safety and Efficacy of ULSC on Disease Severity and Steroid Tapering in Participants With Dermatomyositis/ Polymyositis (DM/PM), Also Known as Idiopathic Inflammatory Myopathy (IIM)
NCT07160205 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis
NCT06744920 ·Status: RECRUITING ·Phase: PHASE3
-
A Phase 1b/2 Study of IM-101 in Adult Participants With Generalized Myasthenia Gravis and Ocular Myasthenia Gravis
NCT07250750 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of RVT-1401 in Myasthenia Gravis (MG) Patients
NCT03863080 ·Status: COMPLETED ·Phase: PHASE2