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Cellular Immunity, Neuroendocrine, and Inflammatory Factors for Clinical Prognosis in Acute Coronary Syndrome

NCT06513611 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2024-07-22

No results posted yet for this study

Summary

In acute coronary syndrome (ACS), there is an increase in cortisol levels, as an expression of the stress response, and C-reactive protein, as an expression of the inflammatory response, which are in turn associated with changes in the components of cellular immunity, and ultimately are predictors of clinical events. The objective of this study is to demonstrate that, within the frame of reference of ACS, beyond the thrombotic phenomenon that leads to ischemia and myocardial necrosis, there is an activation of an inflammatory and stress response, evidenced by an elevation of CRP and cortisol, respectively, and sequentially modifications in the components of cellular immunity in peripheral blood that convey prognostic value during hospitalization and after discharge. A prospective, observational, analytical, unicentric study of consecutive patients with ACS, with telephone follow-up to 6 months, will be carried out. For 2 years, all eligible patients admitted with a diagnosis of ACS to the Coronary Care Unit of the Hospital de Clínicas José de San Martín in Buenos Aires will be registered consecutively.

Conditions

  • Acute Coronary Syndrome
  • Stress Hyperglycemia
  • Cortisol; Hypersecretion
  • Inflammatory Response
  • Coagulation

Interventions

DIAGNOSTIC_TEST

Serum cortisol.

Serum cortisol levels obtained on admission.

Sponsors & Collaborators

  • University of Buenos Aires

    collaborator OTHER

  • Hospital de Clinicas José de San Martín

    lead OTHER

Principal Investigators

  • Sandra P Sweiszkowski, MD, MSc. · Hospital de Clinicas Jose de San Martin

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-01
Primary Completion
2025-07-01
Completion
2026-07-01

Countries

  • Argentina

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06513611 on ClinicalTrials.gov