Induction Chemotherapy Plus Cadonilimab for Locally Advanced Cervical Cancer
NCT06511726 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 29
Last updated 2025-02-14
Summary
This is a Phase II clinical study for patients with locally advanced cervical cancer, aimed at evaluating the efficacy, safety, and tolerability of Cadonilimab combined with chemotherapy as induction therapy.
Conditions
Interventions
- DRUG
-
Cadonilimab
Induction chemotherapy and immunotherapy: Cadonilimab + cisplatin + albumin-bound paclitaxel, for a total of 2 cycles (cisplatin 75 mg/m² + albumin-bound paclitaxel 260 mg/m² q3w, Cadonilimab 10 mg/kg q3w).
Sponsors & Collaborators
-
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
lead OTHER
Principal Investigators
-
Shoumin Bai · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- FEMALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-01-23
- Primary Completion
- 2025-10-30
- Completion
- 2027-10-30
Countries
- China
Study Locations
More Related Trials
-
Chemotherapy Plus Radiation Therapy in Treating Patients With Primary Stage IVB Cervical Cancer
NCT03175848 ·Status: UNKNOWN ·Phase: NA
-
A Single-Arm, Phase II Clinical Trail of Cadonilimab Combined With Chemoradiotherapy in Oligometastatic Stage IVB Cervical Cancer
NCT06998394 ·Status: RECRUITING ·Phase: PHASE2
-
Nab-Paclitaxel Plus Cisplatin With Concurrent Radiotherapy for Patients With Locally Advanced Cervical Cancer: A Multicentre, Single-arm, Phase II Trial.
NCT06426056 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
CNCMT:a Multi-center, Prospective, Single-arm Study
NCT06714084 ·Status: ENROLLING_BY_INVITATION ·Phase: NA
-
A Prospective Real-world Study of Cadonilimab in Patients With Recurrent or Metastatic Cervical Cancer
NCT06155422 ·Status: NOT_YET_RECRUITING
-
Cadonilimab With Chemoradiation for Recurrent and Oligometastatic Endometrial Carcinoma
NCT06532539 ·Status: RECRUITING ·Phase: PHASE2
-
Study of Neoadjuvant Chemotherapy Versus Definite Concurrent Chemoradiotherapy for Locally Advanced Bulk Cervical Cancer
NCT05189028 ·Status: RECRUITING ·Phase: PHASE3
-
Concurrent Chemoradiotherapy Combined With Adjuvant Chemotherapy Treated Advanced Cervical Cancer
NCT05735145 ·Status: RECRUITING ·Phase: PHASE3
-
A Study of Concurrent Chemoradiotherapy Followed by Cadonilimab(AK104) for Newly Diagnosed Local Advanced Cervical Cancer
NCT06251388 ·Status: RECRUITING ·Phase: PHASE2
-
Neoadjuvant Chemoimmunotherapy and Extrafascial Hysterectomy for IB2 Cervical Cancer
NCT06289751 ·Status: RECRUITING ·Phase: PHASE2
-
Adjuvant Chemoradiotherapy Followed by Zimberelimab for Locally Advanced Cervical Cancer.
NCT06128460 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Exploring the Efficacy, Safety and Cost-effectiveness Analysis of Cadonilimab in the Treatment of Cervical Cancer
NCT06140589 ·Status: RECRUITING
-
Comparing Postoperative Adjuvant Cisplatin Concurrent Chemoradiotherapy With Adjuvant Radiotherapy Alone for Intermediate-risk Head and Neck Squamous Cell Carcinoma
NCT07125755 ·Status: RECRUITING ·Phase: PHASE3
-
A Study in Recurrent or Metastatic Cervical Cancer Patients With PD-L1 Positive
NCT03808857 ·Status: UNKNOWN ·Phase: PHASE2
-
Induction Chemotherapy Combined With Immunotherapy Followed by Concurrent Chemoradiation in Advanced Cervical Cancer
NCT05173272 ·Status: RECRUITING ·Phase: PHASE3
-
QL1706 Plus Neoadjuvant Chemotherapy Followed by Type I Hysterectomy for Locally Advanced Cervical Cancer
NCT07205497 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Efficacy and Safety of Caldonirimab Plus Nimotuzumab for Recurrent or Metastatic Cervical Cancer
NCT05606263 ·Status: RECRUITING ·Phase: PHASE2
-
Concurrent Chemoradiotherapy Followed by PD-1 Inhibitor in Advanced Cervical Cancer
NCT06391190 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Cadonilimab Plus Anlotinib for R/M/P Cervical Cancer
NCT05817214 ·Status: RECRUITING ·Phase: PHASE2
-
Study of Cisplatin in Cervical Cancer Stage IVB
NCT00826891 ·Status: UNKNOWN ·Phase: PHASE2
-
Anlotinib Combined With Concurrent Chemoradiotherapy in the Treatment of Locally Advanced Cervical Cancer
NCT05772377 ·Status: UNKNOWN ·Phase: PHASE2
-
VMAT Concurrent Cisplatin Plus Nab-paclitaxel for Local Advanced Cervical Cancer
NCT04017377 ·Status: UNKNOWN ·Phase: NA
-
A Phase II Trial to Evaluate the Efficacy and Safety of QL1706 in Patients With Cervical Cancer
NCT05557565 ·Status: UNKNOWN ·Phase: PHASE2
-
Safety and Efficacy Study of First-line Treatment With QL1706 Plus Chemotherapy With or Without Bevacizumab in Women With Recurrent, or Metastatic Cervical Cancer
NCT05179317 ·Status: UNKNOWN ·Phase: PHASE2
-
Effects of Neoadjuvant Therapy With Carboplatin, Paclitaxel Combined With Anti-PD-1 Drugs on Pain, Anxiety and Depression in Patients With Resectable Head and Neck Squamous Cell Carcinoma
NCT06575322 ·Status: RECRUITING