Trial Outcomes & Findings for Sevoflurane Concentrations in Children (NCT NCT06510803)
NCT ID: NCT06510803
Last Updated: 2026-02-13
Results Overview
We will measure the inspired and expired sevoflurane concentrations using an agent monitor, determine the ratio for each patient during each measurement at 30 seconds for the first 5 minutes of induction and and then every minute until the IV is secured. Data are reported as means and standard deviations at each of the time points and represented in a figure.
Recruitment status
COMPLETED
Target enrollment
24 participants
Primary outcome timeframe
From 0 to 10 minutes of induction of anesthesia
Results posted on
2026-02-13
Participant Flow
Participant milestones
| Measure |
Control is GE Ohmeda Workstation
The washin of sevoflurane in the GE Ohmeda workstation during induction of anesthesia.
The washin of sevoflurane: The increases in the end-tidal to inspired sevoflurane concentrations during induction of anesthesia with the Drager Apollo compared with the GE Ohmeda workstations
|
Intervention is Drager Apollo Workstation
The washin of sevoflurane in the Drager Apollo workstation during induction of anesthesia.
The washin of sevoflurane: The increases in the sevoflurane concentrations during induction of anesthesia with the Drager Apollo compared with the GE Ohmeda workstations
|
|---|---|---|
|
Overall Study
STARTED
|
12
|
12
|
|
Overall Study
COMPLETED
|
12
|
12
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Gender not collected - irrelevant for this study.
Baseline characteristics by cohort
| Measure |
Control is GE Ohmeda Workstation
n=12 Participants
The washin of sevoflurane in the GE Ohmeda workstation during induction of anesthesia.
The washin of sevoflurane: The increases in the end-tidal to inspired sevoflurane concentrations during induction of anesthesia with the Drager Apollo compared with the GE Ohmeda workstations
|
Intervention is Drager Apollo Workstation
n=12 Participants
The washin of sevoflurane in the Drager Apollo workstation during induction of anesthesia.
The washin of sevoflurane: The increases in the sevoflurane concentrations during induction of anesthesia with the Drager Apollo compared with the GE Ohmeda workstations
|
Total
n=24 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Customized
Age
|
3.6 years
STANDARD_DEVIATION 1 • n=12 Participants
|
4.2 years
STANDARD_DEVIATION 1.6 • n=12 Participants
|
3.9 years
STANDARD_DEVIATION 1.3 • n=24 Participants
|
|
Sex: Female, Male
Female
|
—
|
—
|
0 Participants
Gender not collected - irrelevant for this study.
|
|
Sex: Female, Male
Male
|
—
|
—
|
0 Participants
Gender not collected - irrelevant for this study.
|
|
Race and Ethnicity Not Collected
|
—
|
—
|
0 Participants
Race and Ethnicity were not collected from any participant.
|
|
Ratio of alveolar to inspired sevoflurane concentrations
|
0 ratio
STANDARD_DEVIATION 0 • n=12 Participants
|
0 ratio
STANDARD_DEVIATION 0 • n=12 Participants
|
0 ratio
STANDARD_DEVIATION 0 • n=24 Participants
|
PRIMARY outcome
Timeframe: From 0 to 10 minutes of induction of anesthesiaPopulation: Table of the inspired to expired sevoflurane concentration ratios for the GE Ohmeda and Drager Apollo workstations during the first 10 minutes. Analysis was by two-factor repeated measures ANOVA and the Sidak test for multiple comparisons.
We will measure the inspired and expired sevoflurane concentrations using an agent monitor, determine the ratio for each patient during each measurement at 30 seconds for the first 5 minutes of induction and and then every minute until the IV is secured. Data are reported as means and standard deviations at each of the time points and represented in a figure.
Outcome measures
| Measure |
Control is GE Ohmeda Workstation
n=12 Participants
The washin of sevoflurane in the GE Ohmeda workstation during induction of anesthesia.
The washin of sevoflurane: The increases in the sevoflurane concentrations during induction of anesthesia with the Drager Apollo compared with the GE Ohmeda workstations
|
Intervention is Drager Apollo Workstation
n=12 Participants
The washin of sevoflurane in the Drager Apollo workstation during induction of anesthesia.
The washin of sevoflurane: The increases in the sevoflurane concentrations during induction of anesthesia with the Drager Apollo compared with the GE Ohmeda workstations
|
|---|---|---|
|
Ratios of the Inspired to Expired Sevoflurane Concentrations During Induction of Anesthesia
Time 2.5 minutes
|
0.867 ratio
Standard Deviation 0.11
|
0.894 ratio
Standard Deviation 0.082
|
|
Ratios of the Inspired to Expired Sevoflurane Concentrations During Induction of Anesthesia
Time 3 minutes
|
0.886 ratio
Standard Deviation 0.065
|
0.92 ratio
Standard Deviation 0.01
|
|
Ratios of the Inspired to Expired Sevoflurane Concentrations During Induction of Anesthesia
Time 0
|
0 ratio
Standard Deviation 0
|
0 ratio
Standard Deviation 0
|
|
Ratios of the Inspired to Expired Sevoflurane Concentrations During Induction of Anesthesia
TIme 0.5 minutes
|
0.684 ratio
Standard Deviation 0.2
|
0.6615 ratio
Standard Deviation 0.04
|
|
Ratios of the Inspired to Expired Sevoflurane Concentrations During Induction of Anesthesia
Time 1 minute
|
0.816 ratio
Standard Deviation 0.177
|
0.80 ratio
Standard Deviation 0.09
|
|
Ratios of the Inspired to Expired Sevoflurane Concentrations During Induction of Anesthesia
Time 1.5 minutes
|
0.888 ratio
Standard Deviation 0.07
|
0.82 ratio
Standard Deviation 0.03
|
|
Ratios of the Inspired to Expired Sevoflurane Concentrations During Induction of Anesthesia
Time 2 minutes
|
0.88 ratio
Standard Deviation 0.078
|
0.84 ratio
Standard Deviation 0.03
|
|
Ratios of the Inspired to Expired Sevoflurane Concentrations During Induction of Anesthesia
TIme 3.5 minutes
|
0.9 ratio
Standard Deviation 0.066
|
0.92 ratio
Standard Deviation 0.017
|
|
Ratios of the Inspired to Expired Sevoflurane Concentrations During Induction of Anesthesia
Time 4.0 minutes
|
0.85 ratio
Standard Deviation 0.065
|
0.95 ratio
Standard Deviation 0.006
|
|
Ratios of the Inspired to Expired Sevoflurane Concentrations During Induction of Anesthesia
Time 4.5 minutes
|
0.888 ratio
Standard Deviation 0.069
|
0.94 ratio
Standard Deviation 0.016
|
|
Ratios of the Inspired to Expired Sevoflurane Concentrations During Induction of Anesthesia
Time 5 minutes
|
0.87 ratio
Standard Deviation 0.063
|
0.92 ratio
Standard Deviation 0.02
|
|
Ratios of the Inspired to Expired Sevoflurane Concentrations During Induction of Anesthesia
TIme 6 minutes
|
0.87 ratio
Standard Deviation 0.085
|
0.92 ratio
Standard Deviation 0.02
|
|
Ratios of the Inspired to Expired Sevoflurane Concentrations During Induction of Anesthesia
Time 7 minutes
|
0.967 ratio
Standard Deviation 0
|
0.907 ratio
Standard Deviation 0
|
SECONDARY outcome
Timeframe: At 1 minute during induction of anesthesiaPopulation: Student's t test
The maximum percent sevoflurane measured at 1 minute of induction of anesthesia will be summarized as means and standard deviation for each workstation.
Outcome measures
| Measure |
Control is GE Ohmeda Workstation
n=12 Participants
The washin of sevoflurane in the GE Ohmeda workstation during induction of anesthesia.
The washin of sevoflurane: The increases in the sevoflurane concentrations during induction of anesthesia with the Drager Apollo compared with the GE Ohmeda workstations
|
Intervention is Drager Apollo Workstation
n=12 Participants
The washin of sevoflurane in the Drager Apollo workstation during induction of anesthesia.
The washin of sevoflurane: The increases in the sevoflurane concentrations during induction of anesthesia with the Drager Apollo compared with the GE Ohmeda workstations
|
|---|---|---|
|
Maximum Inspired Concentration at 1 Minute of Induction
|
7.8 percent sevoflurane
Standard Deviation 0.67
|
6.4 percent sevoflurane
Standard Deviation 0.4
|
SECONDARY outcome
Timeframe: 10 minutes of induction of anesthesiaThe maximum sevoflurane concentrations (inspired and expired) during the first 10 minutes of induction of anesthesia
Outcome measures
| Measure |
Control is GE Ohmeda Workstation
n=12 Participants
The washin of sevoflurane in the GE Ohmeda workstation during induction of anesthesia.
The washin of sevoflurane: The increases in the sevoflurane concentrations during induction of anesthesia with the Drager Apollo compared with the GE Ohmeda workstations
|
Intervention is Drager Apollo Workstation
n=12 Participants
The washin of sevoflurane in the Drager Apollo workstation during induction of anesthesia.
The washin of sevoflurane: The increases in the sevoflurane concentrations during induction of anesthesia with the Drager Apollo compared with the GE Ohmeda workstations
|
|---|---|---|
|
Maximum Sevoflurane Concentrations During Induction of Anesthesia
|
8.5 percentage of sevoflurane
Standard Deviation 0.4
|
7.2 percentage of sevoflurane
Standard Deviation 0.3
|
SECONDARY outcome
Timeframe: within the first 10 minutes of induction of sevofluraneThe time (minutes) to reach 90% of the maximum inspired sevoflurane concentration during induction of anesthesia.
Outcome measures
| Measure |
Control is GE Ohmeda Workstation
n=12 Participants
The washin of sevoflurane in the GE Ohmeda workstation during induction of anesthesia.
The washin of sevoflurane: The increases in the sevoflurane concentrations during induction of anesthesia with the Drager Apollo compared with the GE Ohmeda workstations
|
Intervention is Drager Apollo Workstation
n=12 Participants
The washin of sevoflurane in the Drager Apollo workstation during induction of anesthesia.
The washin of sevoflurane: The increases in the sevoflurane concentrations during induction of anesthesia with the Drager Apollo compared with the GE Ohmeda workstations
|
|---|---|---|
|
Time to Reach 90% of the Maximum Inspired Concentration
|
0.5 minutes
Interval 0.5 to 0.5
|
1.75 minutes
Interval 1.0 to 2.4
|
Adverse Events
Control is GE Ohmeda Workstation
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Intervention is Drager Apollo Workstation
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place