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Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery

NCT06488001 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 132

Last updated 2025-05-21

No results posted yet for this study

Summary

The goal of this clinical trial is to see if pantoprazole (a proton pump inhibitor used for acid reflux/heart burn) can reduce nausea and vomiting after gynecologic surgery in women between the ages of 18 and 79.

Researchers will compare a placebo to the active medication.

Participants will be asked to take three pills around their surgery, two taken before and one taken the night after.

Conditions

  • Postoperative Nausea and Vomiting

Interventions

DRUG

pantoprazole

Pantoprazole 40mg given the night before surgery, 2 hours prior to surgery, and the evening after surgery.

DRUG

Placebo

Placebo given the night before surgery, 2 hours prior to surgery, and the evening after surgery.

Sponsors & Collaborators

  • United States Naval Medical Center, Portsmouth

    lead FED

Principal Investigators

  • Casey Timmerman, DO · United States Naval Medical Center, Portsmouth

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
79 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-08-26
Primary Completion
2026-12-31
Completion
2026-12-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06488001 on ClinicalTrials.gov