Trial Outcomes & Findings for Effect of a Sequence of Specific Manual Therapy Techniques Targeting the Autonomic Nervous System in Healthy Adults (NCT NCT06477822)

Results Overview

The investigators will examine the difference between Time 1 and Time 2 and between groups in beats per minute.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

96 participants

Primary outcome timeframe

At baseline and immediately post-intervention on Day 1

Results posted on

2026-05-27

Participant Flow

Participant milestones

Participant milestones
Measure	Sequence of Manual Therapy Techniques Participants receive a manual therapy secuence of techniques	Simulated Manual Therapy Techniques Participants receive a sequence of simulated manual therapy techniques
Overall Study STARTED	48	48
Overall Study COMPLETED	48	48
Overall Study NOT COMPLETED	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Sequence of Manual Therapy Techniques n=48 Participants Participants receive a manual therapy secuence of techniques, consisting in 4 techniques: fourth ventricle compression , suboccipital decompression , suboccipital inhibition , and vagus nerve neurodinamic	Simulated Manual Therapy Techniques n=48 Participants Participants receive a sequence of simulated manual therapy techniques, consisting in 4 techniques: fourth ventricle compression simulation, suboccipital decompression simulation, suboccipital inhibition simulation, and vagus nerve neurodinamic simulation	Total n=96 Participants Total of all reporting groups
Age, Continuous	38.27 years STANDARD_DEVIATION 11.38 • n=48 Participants	37.73 years STANDARD_DEVIATION 12.78 • n=48 Participants	38 years STANDARD_DEVIATION 12 • n=96 Participants
Sex: Female, Male Female	20 Participants n=48 Participants	22 Participants n=48 Participants	42 Participants n=96 Participants
Sex: Female, Male Male	28 Participants n=48 Participants	26 Participants n=48 Participants	54 Participants n=96 Participants
Race and Ethnicity Not Collected	—	—	0 Participants Race and Ethnicity were not collected from any participant.
height	172.35 cm STANDARD_DEVIATION 7.62 • n=48 Participants	171 cm STANDARD_DEVIATION 9.17 • n=48 Participants	171.7 cm STANDARD_DEVIATION 8.4 • n=96 Participants

PRIMARY outcome

Timeframe: At baseline and immediately post-intervention on Day 1

The investigators will examine the difference between Time 1 and Time 2 and between groups in beats per minute.

Outcome measures

Outcome measures
Measure	Simulated Manual Therapy Techniques n=48 Participants Participants receive a sequence of simulated manual therapy techniques	Sequence of Manual Therapy Techniques n=48 Participants Participants receive a manual therapy secuence of techniques
Change in Heart Rate	-0.94 beat per minute Standard Deviation 2.41	-2.40 beat per minute Standard Deviation 2.17

PRIMARY outcome

Timeframe: At baseline and immediately post-intervention on Day 1

The investigators will examine the difference between Time 1 and Time 2 and between groups in HRV measured by Root mean square of the successive differences between adjacent RR intervals (RMSSD) in heart rate variability index

Outcome measures

Outcome measures
Measure	Simulated Manual Therapy Techniques n=48 Participants Participants receive a sequence of simulated manual therapy techniques	Sequence of Manual Therapy Techniques n=48 Participants Participants receive a manual therapy secuence of techniques
Change in Root Mean Square of the Successive Differences Between Adjacent RR Intervals (RMSSD) in Heart Rate Variability Index	1.38 ms Standard Deviation 9.88	5.90 ms Standard Deviation 11.61

SECONDARY outcome

Timeframe: At baseline and immediately post-intervention on Day 1

The investigators will examine the difference between Time 1 and Time 2 and between groups in HRV measured by high frequency (HF) power of heart rate variability derived from spectral analysis, reflecting parasympathetic nervous system activity, expressed in milliseconds squared (ms²), within the 0.15-0.40 Hz frequency band

Outcome measures

Outcome measures
Measure	Simulated Manual Therapy Techniques n=48 Participants Participants receive a sequence of simulated manual therapy techniques	Sequence of Manual Therapy Techniques n=48 Participants Participants receive a manual therapy secuence of techniques
Change in High Frequency (HF) Band in Heart Rate Variability Index	9522.77 ms Standard Deviation 81165.78	23343.08 ms Standard Deviation 74193.70

SECONDARY outcome

Timeframe: At baseline and immediately post-intervention on Day 1

The investigators will examine the difference between Time 1 and Time 2 and between groups in breaths per minute.

Outcome measures

Outcome measures
Measure	Simulated Manual Therapy Techniques n=48 Participants Participants receive a sequence of simulated manual therapy techniques	Sequence of Manual Therapy Techniques n=48 Participants Participants receive a manual therapy secuence of techniques
Change in Respiratory Rate	-0.27 breaths per minute Standard Deviation 2.65	-0.88 breaths per minute Standard Deviation 2.66

Adverse Events

Sequence of Manual Therapy Techniques

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Simulated Manual Therapy Techniques

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Ismael Mohamed

UIC

Phone: +34617692253

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place