MedTrace Logo

Speech Motor Learning and Retention (Master Protocol)

NCT06467292 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 330

Last updated 2026-02-19

No results posted yet for this study

Summary

The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well.

Conditions

  • Speech

Interventions

DEVICE

continuous theta-burst stimulation (cTBS)

cTBS stimulation will be applied to different areas of the brain following learning. Stimulation will take place following learning in order to block motor memory retention.

BEHAVIORAL

Adaptation

Auditory adaptation in speech

DEVICE

Single pulse Transcranial magnetic stimulation (TMS)

TMS will be delivered 10 times in each motor evoked potentials (MEP) recording block.

DEVICE

fMRI

To assess functional connectivity patterns between regions that predict learning.

Sponsors & Collaborators

  • National Institute on Deafness and Other Communication Disorders (NIDCD)

    collaborator NIH

  • Yale University

    lead OTHER

Principal Investigators

  • David Ostry · Yale University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-10-01
Primary Completion
2028-11-30
Completion
2029-05-31
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06467292 on ClinicalTrials.gov