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The Optimal Timing of Vaccination in Pregnancy

NCT06466629 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 96

Last updated 2024-06-20

No results posted yet for this study

Summary

The central aim of this study is to investigate the optimal timing of vaccination in pregnant women. Therefore, pregnant women will be vaccinated against pertussis at different timepoints and blood and breast milk samples will be taken at several timepoints. The main objectives are to assess the impact of timing on humoral and cellular immune responses in pregnant women, on antibody characteristics transferred across the placenta and on transplacental transport efficiency. The impact of maternal pertussis vaccination and timing of maternal pertussis vaccination on breastmilk antibody composition will also be investigated, as well as the impact of vaccination during pregnancy on the mucosal uptake of breastmilk IgA antibodies by the infant respiratory and gastrointestinal tract.

Conditions

  • Pertussis/Whooping Cough

Interventions

BIOLOGICAL

Triaxis, Sanofi Pasteur

tetanus, diphtheria, acellular pertussis (aP) (Tdap) vaccine

Sponsors & Collaborators

  • Université Libre de Bruxelles

    collaborator OTHER

  • Elke Leuridan, MD, PhD

    lead OTHER

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-07-01
Primary Completion
2024-10-31
Completion
2025-04-30

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06466629 on ClinicalTrials.gov