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Association Between Serum and Neuroimaging Measurements of the GABAergic System

NCT06464172 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-02-17

No results posted yet for this study

Summary

The goal of this study is to better understand the relationship between peripheral and central nervous system measurements of the gamma-aminobutyric acid (GABA) system in otherwise healthy individuals. the main questions it aims to answer are:

1. Does GABA cross the blood-brain barrier?
2. Can peripheral measurements of the GABAergic system be used to study GABA in the brain?

Participants will receive oral GABA and Placebo and undergo blood draws, MRI scans and transcranial magnetic stimulation sessions.

Conditions

  • GABAergic System

Interventions

OTHER

Acute Oral gamma-aminobutyric acid (Natural Health Product in Canada)

1800 mg (3 capsules of 600mg) of GABA taken at the research center under the supervision of the research team.

OTHER

Acute Placebo

A capsule filled with powdered sugar taken under the supervision of the research team.

Sponsors & Collaborators

  • Francois Corbin

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-05-05
Primary Completion
2026-05-01
Completion
2026-07-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06464172 on ClinicalTrials.gov