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MRSI Evaluation for Minor Stroke With Large Vessel Occlusion

NCT06457217 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 75

Last updated 2024-10-16

No results posted yet for this study

Summary

The goal of this observational study is to understand acute anterior circulation large artery occluded minor stroke (LVO-MIS) evolution using magnetic resonance spectroscopic imaging evaluation. The main questions it aims to answer are:

1. Neurometabolic predictors of early neurological deterioration and functional outcome;
2. Temporal and spatial dynamic changes of the neurometabolites from the acute stage (within 24 hours), through the subacute stage (5-7 days), to the chronic stage (90 days);
3. Temporal and spatial dynamic changes of the neurotransmitters GABA, glutamate, and glutamine from the acute stage to the chronic stage;
4. Brain regions exhibiting changes in whole-brain metabolic network connectivity.

Conditions

  • Acute Ischemic Stroke

Interventions

DIAGNOSTIC_TEST

Magnetic resonance spectroscopic imaging

High-resolution 3D metabolic imaging was performed using the SPICE 1H-MRSI sequence.

Sponsors & Collaborators

  • Shanghai 6th People's Hospital

    lead OTHER

Principal Investigators

  • Li Cao, phD · Shanghai Jiao Tong University Affiliated Sixth People's Hospital

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-08-15
Primary Completion
2027-09-30
Completion
2027-12-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06457217 on ClinicalTrials.gov