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Non Motor Symptoms in Glucocerebrosidase-related Parkinson's Disease

NCT06451419 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2024-06-28

No results posted yet for this study

Summary

The goal of this observational study is to describe non motor symptoms in a prospective study of patients with Parkinson's disease associated to glucocerebrosidase (GBA-PD) mutations.

The main questions it aims to answer are:

* Do GBA-PD patients have a greater burden of non motor symptoms?
* How do these non motor symptoms evolve during a prospective follow up of two years?
* Are these non motor symptoms different from those that affect Parkinson's disease patients without glucocerebrosidase mutations (non GBA-PD), in prevalence, severity and type?
* Do these non motor symptoms correlate with objective measures such as posturography or speed reaction tests?
* Is there a test or combination of tests that can predict the appearance of early or severe non motor symptoms?

For this reason researchers will compare the GBA-PD group of patients with a group of non mutated GBA Parkinson disease.

Participants will undergo a neurological and neuropsychological evaluation with different tests in subsequent visits for a total of 2 years.

Conditions

  • Parkinson Disease

Interventions

OTHER

Tests on non motor symptoms

Neurological, neuropsychological and self-administered tests on non motor symptoms, including posturography and speed reaction times.

Sponsors & Collaborators

  • Fundación de Investigación Biomédica - Hospital Universitario de La Princesa

    collaborator OTHER

  • Juan Pablo Romero. MD, PhD

    lead OTHER

Principal Investigators

  • Inés Muro, MD · Hospital Universitario La Princesa

  • Juan P Romero, PhD · Universidad Francisco de Vitoria

  • Lydia López, MD · Hospital Universitario La Princesa

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-07-01
Primary Completion
2026-06-30
Completion
2026-08-31

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06451419 on ClinicalTrials.gov