Trial Outcomes & Findings for Examining the Role of Pain in the Link Between Early Childhood Adversity and Psychopathology (NCT NCT06445712)

NCT ID: NCT06445712

Last Updated: 2026-01-27

Results Overview

Time hand is held in cold water

Recruitment status

COMPLETED

Study phase

Target enrollment

39 participants

Primary outcome timeframe

0-120 seconds

Results posted on

2026-01-27

Participant Flow

Participant milestones

Participant milestones
Measure	Pain Assessment Children will submerge their hand in cold water and be asked to hold it in as long as possible. They will do this both alone and holding the hand of a parent (counterbalanced). Parental Support Cold Pressor Task: Child will submerge their hand in cold water alone and holding the hand of a parent.
Overall Study STARTED	39
Overall Study COMPLETED	39
Overall Study NOT COMPLETED	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Examining the Role of Pain in the Link Between Early Childhood Adversity and Psychopathology

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Pain Assessment n=39 Participants Children will submerge their hand in cold water and be asked to hold it in as long as possible. They will do this both alone and holding the hand of a parent (counterbalanced). Parental Support Cold Pressor Task: Child will submerge their hand in cold water alone and holding the hand of a parent.
Age, Categorical <=18 years	39 Participants n=41 Participants
Age, Categorical Between 18 and 65 years	0 Participants n=41 Participants
Age, Categorical >=65 years	0 Participants n=41 Participants
Age, Continuous	8.55 years STANDARD_DEVIATION 1.10 • n=41 Participants
Sex: Female, Male Female	18 Participants n=41 Participants
Sex: Female, Male Male	21 Participants n=41 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	4 Participants n=41 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	35 Participants n=41 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants n=41 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=41 Participants
Race (NIH/OMB) Asian	0 Participants n=41 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=41 Participants
Race (NIH/OMB) Black or African American	5 Participants n=41 Participants
Race (NIH/OMB) White	34 Participants n=41 Participants
Race (NIH/OMB) More than one race	0 Participants n=41 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants n=41 Participants
Region of Enrollment United States	39 Participants n=41 Participants

PRIMARY outcome

Timeframe: 0-120 seconds

Time hand is held in cold water

Outcome measures

Outcome measures
Measure	Pain Assessment n=39 Participants Children will submerge their hand in cold water and be asked to hold it in as long as possible. They will do this both alone and holding the hand of a parent (counterbalanced). Parental Support Cold Pressor Task: Child will submerge their hand in cold water alone and holding the hand of a parent.
Pain Tolerance Time Alone	44.72 seconds Standard Deviation 35.51
Pain Tolerance Time Parent	45.09 seconds Standard Deviation 35.91

PRIMARY outcome

Timeframe: 0-60 seconds after experiencing stimulus

Self-reported score on the Visual Analogue Scale for Pain. Participants use a physical sliding scale to indicate how much pain they experienced \[ higher numbers are equal to more pain; (no pain (0-4 mm), mild pain(5-44 mm), moderate pain (45-74 mm), and severe pain (75-100 mm)\]

Outcome measures

Outcome measures
Measure	Pain Assessment n=39 Participants Children will submerge their hand in cold water and be asked to hold it in as long as possible. They will do this both alone and holding the hand of a parent (counterbalanced). Parental Support Cold Pressor Task: Child will submerge their hand in cold water alone and holding the hand of a parent.
Pain Sensitivity VAS_Alone	5.87 units on a scale Standard Deviation 2.79
Pain Sensitivity VAS_Parent	5.13 units on a scale Standard Deviation 2.67

Adverse Events

Pain Assessment

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Susan Perlman

Washington University in St. Louis

Phone: 3142861700

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place