Trial Outcomes & Findings for Self-Administered Relaxing Acupressure to Reduce Fatigue in Adolescent and Young Adult Cancer Survivors (NCT NCT06442891)
NCT ID: NCT06442891
Last Updated: 2026-06-23
Results Overview
Self-administered acupressure implementation will be feasible if all participants are recruited over 2 years. Descriptive statistics will be used to summarize recruitment rate.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
42 participants
Primary outcome timeframe
1 year
Results posted on
2026-06-23
Participant Flow
Participant milestones
| Measure |
ARM I (Relaxing Acupressure)
Patients received access to acupressure mobile application and self-administer relaxing acupressure to 9 acupoints over 27 minutes QD for 6 weeks.
Acupressure Therapy: Self-administer relaxing acupressure
Internet-Based Intervention: Receive access to acupressure mobile app
Interview: Ancillary studies
Questionnaire Administration: Ancillary studies
|
ARM II (Sham Acupressure)
Patients received access to acupressure mobile application and self-administer sham acupressure to non-acupressure point locations over 27 minutes QD for 6 weeks.
Acupressure Therapy: Self-administer sham acupressure
Internet-Based Intervention: Receive access to acupressure mobile app
Interview: Ancillary studies
Questionnaire Administration: Ancillary studies
|
|---|---|---|
|
Intervention
STARTED
|
30
|
12
|
|
Intervention
COMPLETED
|
30
|
12
|
|
Intervention
NOT COMPLETED
|
0
|
0
|
|
Follow Up
STARTED
|
30
|
12
|
|
Follow Up
COMPLETED
|
20
|
11
|
|
Follow Up
NOT COMPLETED
|
10
|
1
|
Reasons for withdrawal
| Measure |
ARM I (Relaxing Acupressure)
Patients received access to acupressure mobile application and self-administer relaxing acupressure to 9 acupoints over 27 minutes QD for 6 weeks.
Acupressure Therapy: Self-administer relaxing acupressure
Internet-Based Intervention: Receive access to acupressure mobile app
Interview: Ancillary studies
Questionnaire Administration: Ancillary studies
|
ARM II (Sham Acupressure)
Patients received access to acupressure mobile application and self-administer sham acupressure to non-acupressure point locations over 27 minutes QD for 6 weeks.
Acupressure Therapy: Self-administer sham acupressure
Internet-Based Intervention: Receive access to acupressure mobile app
Interview: Ancillary studies
Questionnaire Administration: Ancillary studies
|
|---|---|---|
|
Follow Up
Lost to Follow-up
|
7
|
1
|
|
Follow Up
Lack of time
|
3
|
0
|
Baseline Characteristics
Self-Administered Relaxing Acupressure to Reduce Fatigue in Adolescent and Young Adult Cancer Survivors
Baseline characteristics by cohort
| Measure |
ARM I (Relaxing Acupressure)
n=30 Participants
Patients received access to acupressure mobile application and self-administer relaxing acupressure to 9 acupoints over 27 minutes QD for 6 weeks.
Acupressure Therapy: Self-administer relaxing acupressure
Internet-Based Intervention: Receive access to acupressure mobile app
Interview: Ancillary studies
Questionnaire Administration: Ancillary studies
|
ARM II (Sham Acupressure)
n=12 Participants
Patients received access to acupressure mobile application and self-administer sham acupressure to non-acupressure point locations over 27 minutes QD for 6 weeks.
Acupressure Therapy: Self-administer sham acupressure
Internet-Based Intervention: Receive access to acupressure mobile app
Interview: Ancillary studies
Questionnaire Administration: Ancillary studies
|
Total
n=42 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
31.6 years
STANDARD_DEVIATION 6.5 • n=20 Participants
|
29.4 years
STANDARD_DEVIATION 8.0 • n=20 Participants
|
31.0 years
STANDARD_DEVIATION 6.9 • n=40 Participants
|
|
Sex: Female, Male
Female
|
24 Participants
n=20 Participants
|
10 Participants
n=20 Participants
|
34 Participants
n=40 Participants
|
|
Sex: Female, Male
Male
|
6 Participants
n=20 Participants
|
2 Participants
n=20 Participants
|
8 Participants
n=40 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
1 Participants
n=20 Participants
|
2 Participants
n=20 Participants
|
3 Participants
n=40 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
29 Participants
n=20 Participants
|
10 Participants
n=20 Participants
|
39 Participants
n=40 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=20 Participants
|
0 Participants
n=20 Participants
|
0 Participants
n=40 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=20 Participants
|
0 Participants
n=20 Participants
|
0 Participants
n=40 Participants
|
|
Race (NIH/OMB)
Asian
|
4 Participants
n=20 Participants
|
0 Participants
n=20 Participants
|
4 Participants
n=40 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=20 Participants
|
0 Participants
n=20 Participants
|
0 Participants
n=40 Participants
|
|
Race (NIH/OMB)
Black or African American
|
0 Participants
n=20 Participants
|
1 Participants
n=20 Participants
|
1 Participants
n=40 Participants
|
|
Race (NIH/OMB)
White
|
25 Participants
n=20 Participants
|
11 Participants
n=20 Participants
|
36 Participants
n=40 Participants
|
|
Race (NIH/OMB)
More than one race
|
0 Participants
n=20 Participants
|
0 Participants
n=20 Participants
|
0 Participants
n=40 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
1 Participants
n=20 Participants
|
0 Participants
n=20 Participants
|
1 Participants
n=40 Participants
|
|
Region of Enrollment
United States
|
30 participants
n=20 Participants
|
12 participants
n=20 Participants
|
42 participants
n=40 Participants
|
PRIMARY outcome
Timeframe: 1 yearPopulation: 42 participants occurred over approximately 12 months (October 1, 2024 to September 23, 2025)
Self-administered acupressure implementation will be feasible if all participants are recruited over 2 years. Descriptive statistics will be used to summarize recruitment rate.
Outcome measures
| Measure |
ARM I (Relaxing Acupressure)
n=30 Participants
Patients received access to acupressure mobile application and self-administer relaxing acupressure to 9 acupoints over 27 minutes QD for 6 weeks.
Acupressure Therapy: Self-administer relaxing acupressure
Internet-Based Intervention: Receive access to acupressure mobile app
Interview: Ancillary studies
Questionnaire Administration: Ancillary studies
|
ARM II (Sham Acupressure)
n=12 Participants
Patients received access to acupressure mobile application and self-administer sham acupressure to non-acupressure point locations over 27 minutes QD for 6 weeks.
Acupressure Therapy: Self-administer sham acupressure
Internet-Based Intervention: Receive access to acupressure mobile app
Interview: Ancillary studies
Questionnaire Administration: Ancillary studies
|
|---|---|---|
|
Recruitment Rate
|
30 participants
|
12 participants
|
PRIMARY outcome
Timeframe: At 6 weeksSelf-administered acupressure implementation will be feasible if 60% of participants complete the baseline and 6-week patient-reported measures and if 60% of acupressure group participants self-report acupressure practice for at least 27 minutes on at least 3 days per week. Descriptive statistics will be used to summarize adherence.
Outcome measures
| Measure |
ARM I (Relaxing Acupressure)
n=30 Participants
Patients received access to acupressure mobile application and self-administer relaxing acupressure to 9 acupoints over 27 minutes QD for 6 weeks.
Acupressure Therapy: Self-administer relaxing acupressure
Internet-Based Intervention: Receive access to acupressure mobile app
Interview: Ancillary studies
Questionnaire Administration: Ancillary studies
|
ARM II (Sham Acupressure)
n=12 Participants
Patients received access to acupressure mobile application and self-administer sham acupressure to non-acupressure point locations over 27 minutes QD for 6 weeks.
Acupressure Therapy: Self-administer sham acupressure
Internet-Based Intervention: Receive access to acupressure mobile app
Interview: Ancillary studies
Questionnaire Administration: Ancillary studies
|
|---|---|---|
|
Number of Participants With Adherence
|
11 Participants
|
5 Participants
|
SECONDARY outcome
Timeframe: baseline, 6 weeks, and 10 weeks after starting treatmentPopulation: Acupressure arm: 7 lost to follow up; 3 discontinued interventions due to lack of time Sham: 1 patient lost to follow up, and 2 did not complete the questionnaire
Measured using the Patient Reported Outcomes Measurement Information Systems Fatigue 4a questionnaire. Results are continuously scaled and appropriately analyzed by Gaussian-based statistical models. Change in fatigue will be analyzed using a Full Information Maximum Likelihood mixed-effects linear regression model. Specifically, change from baseline will be evaluated by including fixed-effects coefficients for time, treatment, and the important interaction effects that will determine whether changes from baseline are greater in the relaxing acupressure group, relative to controls. Random Y-intercepts in the model will be incorporated to accommodate the nesting of repeated observations within subject. Change in fatigue will be analyzed using a Full Information Maximum Likelihood mixed-effects linear regression model. Range score is 30-80 and increasing scores indicate worse symptoms.
Outcome measures
| Measure |
ARM I (Relaxing Acupressure)
n=30 Participants
Patients received access to acupressure mobile application and self-administer relaxing acupressure to 9 acupoints over 27 minutes QD for 6 weeks.
Acupressure Therapy: Self-administer relaxing acupressure
Internet-Based Intervention: Receive access to acupressure mobile app
Interview: Ancillary studies
Questionnaire Administration: Ancillary studies
|
ARM II (Sham Acupressure)
n=12 Participants
Patients received access to acupressure mobile application and self-administer sham acupressure to non-acupressure point locations over 27 minutes QD for 6 weeks.
Acupressure Therapy: Self-administer sham acupressure
Internet-Based Intervention: Receive access to acupressure mobile app
Interview: Ancillary studies
Questionnaire Administration: Ancillary studies
|
|---|---|---|
|
Change in Fatigue
6 Weeks
|
49.99 score on a scale
Interval 46.89 to 53.1
|
54.62 score on a scale
Interval 50.36 to 58.87
|
|
Change in Fatigue
10 Weeks
|
50.73 score on a scale
Interval 47.63 to 53.84
|
54.45 score on a scale
Interval 49.82 to 59.08
|
|
Change in Fatigue
Baseline
|
60.11 score on a scale
Interval 57.52 to 62.7
|
62.69 score on a scale
Interval 58.6 to 66.79
|
SECONDARY outcome
Timeframe: 6 weeks after starting treatmentPopulation: Acupressure arm: 7 lost to follow up; 3 discontinued interventions due to lack of time Sham: 1 patient lost to follow up
Interview data will be analyzed using inductive content analysis. Perspectives of the intervention will be analyzed using inductive content analysis. (1 - 5, higher scores = greater acceptability) from the Acceptability E-Scale (Tariman et al., 2011) applies to all rows listed
Outcome measures
| Measure |
ARM I (Relaxing Acupressure)
n=20 Participants
Patients received access to acupressure mobile application and self-administer relaxing acupressure to 9 acupoints over 27 minutes QD for 6 weeks.
Acupressure Therapy: Self-administer relaxing acupressure
Internet-Based Intervention: Receive access to acupressure mobile app
Interview: Ancillary studies
Questionnaire Administration: Ancillary studies
|
ARM II (Sham Acupressure)
n=11 Participants
Patients received access to acupressure mobile application and self-administer sham acupressure to non-acupressure point locations over 27 minutes QD for 6 weeks.
Acupressure Therapy: Self-administer sham acupressure
Internet-Based Intervention: Receive access to acupressure mobile app
Interview: Ancillary studies
Questionnaire Administration: Ancillary studies
|
|---|---|---|
|
Acceptability E - Scale
How easy was it for you to practice self-administered acupressure during the study?
|
4 score on a scale
Interval 1.0 to 5.0
|
4 score on a scale
Interval 2.0 to 5.0
|
|
Acceptability E - Scale
How understandable was the content presented in the acupressure app?
|
5 score on a scale
Interval 3.0 to 5.0
|
5 score on a scale
Interval 4.0 to 5.0
|
|
Acceptability E - Scale
How much did you enjoy practicing self-administered acupressure?
|
3 score on a scale
Interval 1.0 to 5.0
|
3 score on a scale
Interval 1.0 to 5.0
|
|
Acceptability E - Scale
How helpful was self-administered acupressure in managing fatigue?
|
3 score on a scale
Interval 1.0 to 5.0
|
2 score on a scale
Interval 1.0 to 5.0
|
|
Acceptability E - Scale
Was the frequency (daily) of the self-administered acupressure intervention acceptable?
|
3.5 score on a scale
Interval 1.0 to 5.0
|
3 score on a scale
Interval 2.0 to 5.0
|
|
Acceptability E - Scale
Was the length (27 min) of each self-administered acupressure session acceptable?
|
3 score on a scale
Interval 1.0 to 5.0
|
3 score on a scale
Interval 2.0 to 4.0
|
|
Acceptability E - Scale
Overall, how would you rate your satisfaction with the self-administered acupressure intervention?
|
3 score on a scale
Interval 1.0 to 5.0
|
3 score on a scale
Interval 2.0 to 4.0
|
Adverse Events
ARM I (Relaxing Acupressure)
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
ARM II (Sham Acupressure)
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
University of Michigan Rogel Cancer Center ClinicalTrials.gov Admin
University of Michigan Rogel Cancer Center
Phone: 734-936-9499
Email: [email protected]
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place