Trial Outcomes & Findings for Interleukin-2 (IL-2), Interleukin-5 (IL-5) and Interleukin-17 (IL-17) Levels of Patients With Stainless Steel Crowns (NCT NCT06439095)
NCT ID: NCT06439095
Last Updated: 2025-06-18
Results Overview
Relative gene expression analysis was performed using quantitative PCR (qPCR) with appropriate primers. The results were reported as fold change relative to baseline values.
COMPLETED
12 participants
Sample collection at baseline (Day 0) and 7 days after treatment
2025-06-18
Participant Flow
Participants were recruited from pediatric dental clinics and selected based on the need for stainless steel crown placement.
Twelve patients were enrolled according to the study protocol and all twelve commenced the study.
Participant milestones
| Measure |
Stainless Steel Crown Group
Patients received stainless steel crowns, and salivary IL-2, IL-5, and IL-17 gene expression levels were measured at baseline and after 7 days.
|
|---|---|
|
Overall Study
STARTED
|
12
|
|
Overall Study
COMPLETED
|
10
|
|
Overall Study
NOT COMPLETED
|
2
|
Reasons for withdrawal
| Measure |
Stainless Steel Crown Group
Patients received stainless steel crowns, and salivary IL-2, IL-5, and IL-17 gene expression levels were measured at baseline and after 7 days.
|
|---|---|
|
Overall Study
Lost to Follow-up
|
2
|
Baseline Characteristics
Race and Ethnicity were not collected from any participant.
Baseline characteristics by cohort
| Measure |
Stainless Steel Crown Group
n=10 Participants
Patients received stainless steel crowns, and salivary IL-2, IL-5, and IL-17 gene expression levels were measured at baseline and after 7 days.
|
|---|---|
|
Age, Continuous
|
6.4 Years
STANDARD_DEVIATION 1.0 • n=10 Participants
|
|
Sex: Female, Male
Female
|
6 Participants
n=10 Participants
|
|
Sex: Female, Male
Male
|
4 Participants
n=10 Participants
|
|
Baseline IL-2, IL-5, and IL-17 Expression Status
Baseline IL-2 Expression (Relative Units)
|
1.0 Relative Expression Units
STANDARD_DEVIATION 0.1 • n=10 Participants
|
|
Baseline IL-2, IL-5, and IL-17 Expression Status
Baseline IL-5 Expression (Relative Units)
|
1.0 Relative Expression Units
STANDARD_DEVIATION 0.15 • n=10 Participants
|
|
Baseline IL-2, IL-5, and IL-17 Expression Status
Baseline IL-17 Expression (Relative Units)
|
1.0 Relative Expression Units
STANDARD_DEVIATION 0.2 • n=10 Participants
|
PRIMARY outcome
Timeframe: Sample collection at baseline (Day 0) and 7 days after treatmentPopulation: Of 12 enrolled participants, data from 10 participants were included in the final analysis due to complete sample availability.
Relative gene expression analysis was performed using quantitative PCR (qPCR) with appropriate primers. The results were reported as fold change relative to baseline values.
Outcome measures
| Measure |
Stainless Steel Crown Group
n=10 Participants
Patients received stainless steel crowns on posterior teeth. Salivary IL-2, IL-5, and IL-17 gene expression levels were measured before treatment and 7 days after.
|
|---|---|
|
IL-2, IL-5, IL-17 Expression Level (Fold Change)
Day 7 IL-2 Expression (Fold Change)
|
1.2 Fold Change
Standard Deviation 0.4
|
|
IL-2, IL-5, IL-17 Expression Level (Fold Change)
Day 7 IL-5 Expression (Fold Change)
|
1.8 Fold Change
Standard Deviation 0.3
|
|
IL-2, IL-5, IL-17 Expression Level (Fold Change)
Day 7 IL-17 Expression (Fold Change)
|
4.5 Fold Change
Standard Deviation 1.7
|
Adverse Events
Stainless Steel Crown Group
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Dr. Burçin Avcı, Assistant Professor
Van Yuzuncu Yil University Faculty of Dentistry
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place