Clinical Treatment of Refractory Breast Cancer Based on Organoid Drug Sensitivity Results
NCT06438055 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40
Last updated 2024-05-31
Summary
This study aims to enroll refractory breast cancer patients. Patient-derived organoid will be established, and drug sensitivity test will be conducted to intervene in the selection of clinical treatment plans. Efficacy evaluation and prognosis analysis will also be conducted. It is hoped that this study will provide a basis for the development of personalized treatment plans.
Conditions
- Refractory Breast Cancer
Interventions
- OTHER
-
Chemotherapy and targeted-therapy guided by organoid drug sensitivity test
This study conducts drug sensitivity tests on various clinically approved drugs. The most sensitive drug for the patient is selected for treatment. This study aims to evaluate the clinical effectiveness of treatment plans guided by organoid drug sensitivity tests.
Sponsors & Collaborators
-
Kingbio Medical (Beijing) Co., Ltd.
collaborator UNKNOWN -
Tianjin Medical University Cancer Institute and Hospital
lead OTHER
Principal Investigators
-
Yehui Shi, PhD · Tianjin Cancer Hospital
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- FEMALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-06-30
- Primary Completion
- 2025-06-30
- Completion
- 2026-06-30
More Related Trials
-
A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Unresectable Locally Advanced, Recurrent, or Metastatic HR+HER2- Breast Cancer(PANKU-Breast01)
NCT06343948 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
DP303c Versus Trastuzumab Emtansine in in Patients With HER2-positive Advanced Breast Cancer
NCT06313086 ·Status: RECRUITING ·Phase: PHASE3
-
Reverse HER2-negative Immune Resistant Breast Cancer
NCT06731140 ·Status: RECRUITING ·Phase: PHASE2
-
Clinical Study of QL1706 in Combination With Olaparib for the Treatment of Patients With Previously Treated Homologous Recombination Repair-Deficient Recurrent or Metastatic Triple-Negative Breast Cancer
NCT07005583 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Phase 1 Clinical Trial to Evaluate the Safety and Anti-Tumor Activity of AB-201
NCT06341647 ·Status: WITHDRAWN ·Phase: PHASE1
-
Anlotinib-based Combination Therapy in Patients with Hormone Receptor-positive(HR+) Metastatic Breast Cancer(MBC) .
NCT06734533 ·Status: RECRUITING
-
A Study of TQB2102 for Injection in Patients With Recurrent/Metastatic Breast Cancer
NCT06115902 ·Status: RECRUITING ·Phase: PHASE1
-
The Clinical Trial of TQB2102 for Injection Against Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer
NCT06452706 ·Status: RECRUITING ·Phase: PHASE2
-
Entinostat in Chinese Postmenopausal Women Patients With Locally Recurrent or Metastatic Breast Cancer
NCT02833155 ·Status: COMPLETED ·Phase: PHASE1
-
Study of the Pharmacokinetics and Safety of Trastuzumab Emtansine in Chinese Participants With Locally Advanced Inoperable or Metastatic HER2+ Breast Cancer
NCT03153163 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Unresectable Locally Advanced or Recurrent Metastatic Triple-negative Breast Cancer
NCT06471205 ·Status: RECRUITING ·Phase: PHASE2
-
A Phase 2 Study to Evaluate the Efficacy, Safety and Pharmacokinetics of YL202 in Patients With BC
NCT06439771 ·Status: RECRUITING ·Phase: PHASE2
-
A Single-Arm Phase Ⅱ Study of Fluzoparib Maintenance in Platinum-sensitive Advanced Triple-Negative Breast Cance
NCT07321015 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
QL1706 Plus Chemotherapy as Neoadjuvant Therapy in Early High-Risk TNBC Breast Cancer
NCT06404736 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
BGB-43395 Alone or as Part of Combination Therapies in Chinese Participants With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors
NCT06253195 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Study of BL-B01D1 in Patients With Unresectable Locally Advanced or Metastatic Breast Cancer and Other Solid Tumors
NCT05470348 ·Status: RECRUITING ·Phase: PHASE1
-
Precise Therapy for Refractory HER2 Positive Advanced Breast Cancer
NCT05429684 ·Status: UNKNOWN ·Phase: PHASE3
-
Anti PD-L1 Antibody + Anti CTLA-4 Antibody in Combination With Hormone Therapy in Patients With Hormone Receptor Positive HER2-negative Recurrent or Metastatic Breast Cancer
NCT03430466 ·Status: TERMINATED ·Phase: PHASE2
-
A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer
NCT06340568 ·Status: RECRUITING ·Phase: PHASE3
-
A Study of BL0175 Injection in Postmenopausal Female Adults With HR-positive, Locally Advanced or Metastatic Cancer
NCT06738966 ·Status: RECRUITING ·Phase: PHASE1
-
Efficacy and Safety of Trastuzumab Emtansine in Chinese Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Locally Advanced or Metastatic Breast Cancer
NCT03084939 ·Status: COMPLETED ·Phase: PHASE3
-
Phase I Clinical Study of MBS301 in Treatment of HER2 Positive Recurrent or Metastatic Malignant Solid Tumor
NCT03842085 ·Status: RECRUITING ·Phase: PHASE1
-
Molecularly Targeted Umbrella Study in Luminal Advanced Breast Cancer
NCT04355858 ·Status: UNKNOWN ·Phase: PHASE2
-
DP303c in Patients With HER2-positive Unresectable Locally Advanced, Relapsed, or Metastaticbreast Cancer
NCT05334810 ·Status: UNKNOWN ·Phase: PHASE2
-
Non-Inferiority Study on MRNA-lncRNA Model in Low-Risk Triple-Negative Breast Cancer Patients
NCT06795503 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3