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Efficacy of Human Papillomavirus (HPV) Vaccination to Prevent Infection Among Women Living With HIV.

NCT06436274 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 778

Last updated 2026-01-12

No results posted yet for this study

Summary

The Efficacy of Human Papillomavirus (HPV) Vaccination to Prevent Infection Among Women Living with HIV: A Prospective, Individual, Double-Blind, Randomized Controlled Study is evaluating immediate or delayed single-dose nonavalent HPV vaccination among women living with HIV who received prior HPV vaccination.

Conditions

Interventions

BIOLOGICAL

GARDASIL®9

GARDASIL®9 or equivalent vaccines will be used for this study. These are FDA-approved vaccines.

BIOLOGICAL

Menveo®/Menactra®

Menveo®/Menactra® or equivalent vaccines will be used for this study. These are FDA-approved vaccines.

Sponsors & Collaborators

  • University of Witwatersrand, South Africa

    collaborator OTHER

  • Botswana Harvard Health Partnership

    collaborator UNKNOWN

  • Ministry of Health, Rwanda

    collaborator OTHER_GOV

  • Fred Hutchinson Cancer Center

    collaborator OTHER

  • National Cancer Institute (NCI)

    collaborator NIH

  • Karolinska Institutet

    collaborator OTHER

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Ruanne Barnabas, MBChB, MSc, DPhil · Massachusetts General Hospital

  • Sinead Delany-Moretlwe, MBBCh, PhD, DTM&H · Wits RHI, University of The Witwatersrand

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
16 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-10-14
Primary Completion
2026-12-31
Completion
2027-06-30

Countries

  • Botswana
  • Rwanda
  • South Africa

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06436274 on ClinicalTrials.gov