Prospective Observational Association Between SLCO1B1 Gene Polymorphism and the Anti-factor Xa Activity of Edoxaban in Patients With Moderate to Severe Renal Insufficiency
NCT06431789 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 220
Last updated 2024-05-29
Summary
1. To provide reference for clinical rational use of edoxaban;
2. Optimize the individualized dosing regimen of edoxaban.
Conditions
- Gene Polymorphism
- Edoxaban
- Renal Insufficiency
Sponsors & Collaborators
-
Qianfoshan Hospital
collaborator OTHER -
Yi Han
lead OTHER
Principal Investigators
-
Yi Han, doctorate · Qianfoshan Hospital
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-05-01
- Primary Completion
- 2025-10-31
- Completion
- 2026-04-30
Countries
- China
Study Locations
More Related Trials
-
Dose-finding of Rivaroxaban in Hemodialysis
NCT02047006 ·Status: COMPLETED ·Phase: PHASE4
-
Evaluate the Efficacy and Safety of SHR1459 Tablets in Patients With Primary Membranous Nephropathy
NCT05136456 ·Status: UNKNOWN ·Phase: PHASE2
-
Efficacy, Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Ravulizumab in Chinese Adults Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)
NCT06578949 ·Status: COMPLETED ·Phase: PHASE3
-
Study to Assess the Pharmacokinetics of GSK1278863 in Subjects With End Stage Renal Disease Undergoing Peritoneal Dialysis
NCT02243306 ·Status: COMPLETED ·Phase: PHASE1
-
Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
NCT04344769 ·Status: RECRUITING
-
Open-label, Multiple Ascending Dose Study of Ravulizumab (ALXN1210) in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)
NCT02605993 ·Status: COMPLETED ·Phase: PHASE2
-
Assessment of the Pharmacokinetics of GSK1278863 and Metabolites in Normal Subjects and Subjects With Renal Impairment
NCT01406340 ·Status: TERMINATED ·Phase: PHASE1
-
Safety and Pharmacokinetics Study of MBX 2109 in Adult Subjects With Normal and Impaired Renal Function
NCT06496217 ·Status: COMPLETED ·Phase: PHASE1
-
16-Week Repeat Oral Dose Study of AKB-6548 for Anemia in Participants With End Stage Renal Disease (ESRD) Requiring Chronic Hemodialysis
NCT02260193 ·Status: COMPLETED ·Phase: PHASE2
-
42-Day Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia
NCT01381094 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Kidney Function and Healthy Participants
NCT06190678 ·Status: COMPLETED ·Phase: PHASE1
-
Multiple Dose Study of the Safety, Tolerability, Pharmacokinetics and Effect on Renal Potassium Clearance
NCT01237899 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluation of the Pharmacokinetics and Safety of Inaxaplin in Participants With Mild or Moderate Hepatic Impairment
NCT06529796 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetics of Dabrafenib in Subjects With Renal Impairment
NCT02852239 ·Status: COMPLETED ·Phase: PHASE1
-
Study of the Oral Factor D (FD) Inhibitor ALXN2050 in PNH Patients as Monotherapy
NCT04170023 ·Status: TERMINATED ·Phase: PHASE2
-
Pharmacokinetic Study of Fondaparinux in Outpatients With Renal Dysfunction
NCT00483600 ·Status: WITHDRAWN ·Phase: NA
-
A Study of Roxadustat for the Treatment of Anemia in Participants With Chronic Kidney Disease and Not Receiving Dialysis
NCT01750190 ·Status: COMPLETED ·Phase: PHASE3
-
20-Week Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia
NCT01906489 ·Status: COMPLETED ·Phase: PHASE2
-
PK//PD/Tolerability Study of DA-1229(Evogliptin) in Renal Impaired Patients
NCT02214693 ·Status: COMPLETED ·Phase: PHASE1
-
Study to Evaluate the Pharmacokinetics and Pharmacodynamics of Dabigatran Etexilate in Patients With Stable Severe Renal Disease.
NCT01711853 ·Status: COMPLETED ·Phase: PHASE1
-
A Multi-Center, Open-Label Study
NCT01468259 ·Status: WITHDRAWN ·Phase: PHASE1
-
Safety and Efficacy Study for AKB-6548 in Participants With Chronic Kidney Disease and Anemia
NCT01235936 ·Status: COMPLETED ·Phase: PHASE2
-
PK Study in Subjects With Renal Impairment (Severe and if Required Mild & Moderate) Compared to Subjects With Normal Renal Function
NCT04656795 ·Status: COMPLETED ·Phase: PHASE1
-
Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease (CKD), Not on Dialysis
NCT02174627 ·Status: COMPLETED ·Phase: PHASE3
-
Study on Efficacy and Safety of LNP023 in C3 Glomerulopathy Patients Transplanted and Not Transplanted
NCT03832114 ·Status: COMPLETED ·Phase: PHASE2