Benefits of Combining MCT With CR in the Recovery of Patients With Psychotic Spectrum Disorders

Summary

The goal of this clinical trial is to compare the efficacy of combined REHACOP + MCT alone in persons with nonaffective psychotic disorder in terms of recovery. The main questions it aims to answer are:

* Does combined REHACOP + MCT therapy increase the clinical recovery in persons with nonaffective psychotic disorder (compared to MCT alone)?
* What is the impact of combined REHACOP + MCT therapy compared to MCT therapy alone on personal/psychological recovery, cognitive biases, and social cognition, taking gender differences into account?
* What is the durability of the effects of combined REHACOP + MCT therapy compared to MCT therapy alone on clinical recovery, personal recovery, cognitive biases, and social cognition in the long term?

Researchers will compare REHACOP+MCT therapy to MCT alone to see if there are differences in personal/psychological recovery.

Participants will:

* Participate in Metacognitive Training or in combined REHACOP + Metacognitive training therapy.
* Do 8 weekly sessions of 45-60 minutes (MCT group).
* Do 12 weekly sessions of 45-60 minutes (RECHACOP+MCT group).
* Visit the clinic for checkups and tests.
* Answer self-administered tests.

Conditions

• Schizophrenia
• Schizophreniform Disorders
• Delusional Disorder
• Brief Psychotic Disorder
• Schizoaffective Disorder
• Schizophrenia Spectrum and Other Psychotic Disorders

Interventions

BEHAVIORAL

Cognitive Remediation (REHACOP)

REHACOP is a structured neuropsychological rehabilitation program that covers most of the cognitive deficits present in psychotic disorder: attention, learning and memory, executive functions, language, social cognition, daily life activities, social skills and psychoeducation. The modules of language, social cognition and psychoeducation will not be used in the present clinical trial. Each module includes a hierarchy of exercises based on the cognitive subarea to be worked on and the grade of difficulty demanded for the performance of each task.The format of the sessions will be the same as MCT, that is, groups of 6-10 patients who will receive weekly sessions of 45-60 minutes in length. In this case, the duration of the intervention will be 12 sessions.

BEHAVIORAL

Metacognitive Training (MCT)

The MCT consists in 8 weekly sessions of 45-60 minutes in length. Each group of patients should be made up of 6-10 patients. The material of the training program is available online at: http://www.uke.de/mkt. The material contains 16 powerpoint presentations (2 per each module), one manual and 6 pamphlets of tasks to do at home. The modules are as follows: Module 1: Attribution; Module 2: Jumping to conclusions (1st part); Module 3: Changing beliefs; Module 4: To emphatise (1st part); Module 5: Memory; Module 6: To emphatise (2nd part); Module 7: Jumping to conclusions (2nd part); and Module 8: Self-esteem and mood.

Sponsors & Collaborators

• Parc Sanitari Sant Joan de Déu

  collaborator OTHER

• Consorci Sanitari de Terrassa

  collaborator OTHER

• Hospital de Mataró

  collaborator OTHER

• Centre d'Higiene Mental Les Corts

  collaborator OTHER

• Fundació Els 3 Turons

  collaborator UNKNOWN

• Hospital San Carlos, Madrid

  collaborator OTHER

• Andaluz Health Service

  collaborator OTHER_GOV

• Institut d'Assistència Sanitària

  collaborator OTHER

• Ministerio de Ciencia, Innovación y Universidades

  collaborator UNKNOWN

• Hospital Son Espases

  collaborator OTHER

• Parc Taulí Hospital Universitari

  collaborator OTHER

• Servicio Cántabro de Salud

  collaborator OTHER

• Universitat Autonoma de Barcelona

  lead OTHER

Principal Investigators

• Ana Barajas Velez · Universitat Autonoma de Barcelona

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

16 Years

Max Age

55 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-09-01

Primary Completion

2024-12-31

Completion

2025-12-31

Countries

• Spain

Study Locations