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Simultaneous tDCS and Computerised Gamified Short-term Memory Task Feasibility

NCT06402266 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 13

Last updated 2024-05-07

No results posted yet for this study

Summary

The goal of this observational study is to gain insight into the effects of transcranial direct current stimulation (tDCS) on short-term memory task performance and the feasibility of tDCS in overtly healthy carriers of the susceptibility allele, Apolipoprotein (APOE) ε4, for late-onset Alzheimers disease.

The main questions the study aims to answer are:

* If tDCS is feasible in overtly healthy APOE ε4 carriers using a headset and an app-based short-term memory task.
* If overtly healthy APOE ε4 carriers perform better on a complex short-term memory task when receiving tDCS to the right hemisphere (F4 à PZ) compared to the left hemisphere (F3 à PZ) or sham tDCS.

Participants will be asked to complete an app-based short-term memory task while receiving either tDCS to either the right or left hemisphere or sham stimulation on 3 different days spread out over 1-3 weeks.

Conditions

  • Genetic Predisposition

Interventions

DEVICE

tDCS

The STM task will be combined with respectively two times active tDCS and one sham tDCS. The 3 conditions will be randomised, and both scientific staff and participants will be blinded. Participants will perform the STM task on a tablet for 45 min. Headsets will deliver the tDCS. Two different placements will be used for the active stimulations: 1) F3 and PZ, and 2) F4 and PZ. The current output range will be 1.6mA and the stimulation will last for 30 min. The sham stimulation will function as a control condition. During the sham stimulation, the current density will be ramped up for 15 sec until the current reaches a density of 1.6mA for 60 sec and then again ramped down for 15 sec. After the session, participants will fill out a brief questionnaire regarding their experience. The time interval between sessions will be 1-3 weeks.

Sponsors & Collaborators

  • Aarhus University Hospital

    collaborator OTHER

  • Brain+ ApS

    collaborator UNKNOWN

  • Eurostars EUREKA

    collaborator UNKNOWN

  • Innovation Fund Denmark

    collaborator INDIV

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Jakob U Blicher, Assoc. Prof. · Aarhus University, Centre for Functionally Integrative Neuroscience (CFIN)

Eligibility

Min Age
55 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-07-04
Primary Completion
2022-12-12
Completion
2023-11-23

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06402266 on ClinicalTrials.gov