Trial Outcomes & Findings for Intensive Aerobic and Resistance Exercise Program (IAREP) (NCT NCT06401733)
NCT ID: NCT06401733
Last Updated: 2026-02-19
Results Overview
Pre- and post-intervention measurements were conducted to assess the Risk Stratification Score (RSS). RSS scores range from -3.4 to 6.8; higher scores represent worse outcomes.
COMPLETED
NA
58 participants
Baseline and 12 weeks
2026-02-19
Participant Flow
Participant milestones
| Measure |
Intervention Group
12-week Intensive Aerobic and Resistance Exercise Program (IAREP) intervention group
Intensive Aerobic and Resistance Exercise Program (IAREP): IAREP is a combined aerobic exercise and resistance training program that developed by qualified exercise professionals. It encompasses a 12-week exercise intervention, conducted in a blended mode which consists of face-to-face exercise, Zoom exercise, and pre-recorded video exercise.
Frequency: 3 times exercise per week. Intensity: moderate to vigorous exercise. Time of the exercise: 45-60 mins. Type of exercise: combined aerobic and resistance training.
Warm-up: aerobic workout with dynamic stretch (for targeted muscles). Aerobic exercise: each session encompasses 5 exercise. Resistance training: each session encompasses 4 exercise, 2 upper body exercise and 2 lower body exercise.
Cool-down: relax targeted muscles.
|
Control Group
Subjects that receive their usual care in Jurong polyclinic.
|
|---|---|---|
|
Overall Study
STARTED
|
27
|
31
|
|
Overall Study
COMPLETED
|
25
|
28
|
|
Overall Study
NOT COMPLETED
|
2
|
3
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Intensive Aerobic and Resistance Exercise Program (IAREP)
Baseline characteristics by cohort
| Measure |
Intervention Group
n=25 Participants
12-week Intensive Aerobic and Resistance Exercise Program (IAREP) intervention group
Intensive Aerobic and Resistance Exercise Program (IAREP): IAREP is a combined aerobic exercise and resistance training program that developed by qualified exercise professionals. It encompasses a 12-week exercise intervention, conducted in a blended mode which consists of face-to-face exercise, Zoom exercise, and pre-recorded video exercise.
Frequency: 3 times exercise per week. Intensity: moderate to vigorous exercise. Time of the exercise: 45-60 mins. Type of exercise: combined aerobic and resistance training.
Warm-up: aerobic workout with dynamic stretch (for targeted muscles). Aerobic exercise: each session encompasses 5 exercise. Resistance training: each session encompasses 4 exercise, 2 upper body exercise and 2 lower body exercise.
Cool-down: relax targeted muscles.
|
Control Group
n=28 Participants
Subjects that receive their usual care in Jurong polyclinic.
|
Total
n=53 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Customized
<=60 years
|
7 participants
n=4 Participants
|
7 participants
|
14 participants
n=4 Participants
|
|
Age, Customized
>60 years
|
18 participants
n=4 Participants
|
21 participants
|
39 participants
n=4 Participants
|
|
Sex: Female, Male
Female
|
13 Participants
n=4 Participants
|
13 Participants
|
26 Participants
n=4 Participants
|
|
Sex: Female, Male
Male
|
12 Participants
n=4 Participants
|
15 Participants
|
27 Participants
n=4 Participants
|
|
Race/Ethnicity, Customized
Chinese
|
23 participants
n=4 Participants
|
14 participants
|
37 participants
n=4 Participants
|
|
Race/Ethnicity, Customized
Malay
|
2 participants
n=4 Participants
|
4 participants
|
6 participants
n=4 Participants
|
|
Race/Ethnicity, Customized
Indian
|
0 participants
n=4 Participants
|
8 participants
|
8 participants
n=4 Participants
|
|
Race/Ethnicity, Customized
Others
|
0 participants
n=4 Participants
|
2 participants
|
2 participants
n=4 Participants
|
PRIMARY outcome
Timeframe: Baseline and 12 weeksPopulation: Both intervention and control groups. Post-intervention of RSS scores (cutoff score of 0.3), those higher than 0.3 have a higher risk of cognitive impairment. The lower the score, the lower the risk of cognitive impairment.
Pre- and post-intervention measurements were conducted to assess the Risk Stratification Score (RSS). RSS scores range from -3.4 to 6.8; higher scores represent worse outcomes.
Outcome measures
| Measure |
Intervention
n=25 Participants
IAREP intervention
|
Control
n=28 Participants
Usual care
|
|---|---|---|
|
Change in Cognitive Function Based on Risk Stratification Score (RSS)
Pre
|
-0.2 score on a scale
Interval -1.2 to 0.7
|
-0.1 score on a scale
Interval -0.1 to 2.2
|
|
Change in Cognitive Function Based on Risk Stratification Score (RSS)
Post
|
-0.8 score on a scale
Interval -1.8 to 0.1
|
0.0 score on a scale
Interval -0.9 to 1.7
|
PRIMARY outcome
Timeframe: Baseline and 12 weeksPopulation: Both intervention and control groups.
Pre- and post-intervention measurements were conducted to assess the number of participants with change in cognitive function (Cognitive Impairment). This outcome reports the count of participants with Cognitive Impairment (CI) in each group at both assessments. A decrease in this count from Pre to Post indicates improved group cognitive function; an increase indicates worsened function. CI was diagnosed per Vascular Dementia Battery (VDB) criteria as a score below the clinical cutoff in any of its seven domains: executive function (score range 0-18), attention (score range 0-60), language (score range 0-15), verbal memory (score range 0-110), visual memory (score range 0-117), visuoconstruction (score range 0-97), and visuomotor speed (score range 0-150), where a higher score means a better outcome.
Outcome measures
| Measure |
Intervention
n=25 Participants
IAREP intervention
|
Control
n=28 Participants
Usual care
|
|---|---|---|
|
Number of Participants With Change in Cognitive Function (Cognitive Impairment) Based on Vascular Dementia Battery (VDB)
Pre
|
10 Participants
|
16 Participants
|
|
Number of Participants With Change in Cognitive Function (Cognitive Impairment) Based on Vascular Dementia Battery (VDB)
Post
|
8 Participants
|
14 Participants
|
PRIMARY outcome
Timeframe: Baseline and 12 weeksPopulation: Both intervention and control groups.
Pre- and post-intervention measurements were conducted to assess the Montreal Cognitive Assessment (MoCA). MoCA scores range from 0 to 30, with higher scores indicating better outcomes.
Outcome measures
| Measure |
Intervention
n=25 Participants
IAREP intervention
|
Control
n=28 Participants
Usual care
|
|---|---|---|
|
Change in Cognitive Function Based on the Montreal Cognitive Assessment (MoCA)
Pre
|
25.0 score on a scale
Interval 22.5 to 27.0
|
24.5 score on a scale
Interval 21.3 to 26.0
|
|
Change in Cognitive Function Based on the Montreal Cognitive Assessment (MoCA)
Post
|
25.0 score on a scale
Interval 23.0 to 27.0
|
24.0 score on a scale
Interval 21.5 to 26.8
|
SECONDARY outcome
Timeframe: Baseline and 12 weeksPre- and post-intervention measurements were conducted. Measure the change in blood test of HbA1c for metabolic conditions.
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: Baseline and 12 weeksPre- and post-intervention measurements were conducted. Measure the change in blood tests of IL6, CRP, and TNFa for inflammatory conditions.
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: Baseline and 12 weeksPre- and post-intervention measurements were conducted. Measure the change in Short Physical Performance Battery (SPPB). The scores range from 0 to 12; a higher score means a better outcome.
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: Baseline and 12 weeksPre- and post-intervention measurements were conducted. Measure the change in sarcopenia condition from a rapid sarcopenia screening of Strength, Assistance with walking, Rise from a chair, Climb stairs and Falls (SARC-F). The scores range from 0 to 10; a higher score means a worse outcome.
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: Baseline and 12 weeksPre- and post-intervention measurements were conducted. Measure the change in systolic blood pressure (SBP) and diastolic blood pressure.
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: Baseline and 12 weeksThe IPAQ-SF questionnaire assesses daily physical activities by asking individuals about their engagement in vigorous activities (e.g., heavy lifting), moderate activities (e.g., carrying light loads), and walking over the past 7 days. The IPAQ-SF provides valuable insights into physical activity levels, aiding in health risk assessments and lifestyle improvements.
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: Baseline and 12 weeksPre- and post-intervention measurements were conducted. Measure the change in the Self-care of Diabetes Inventory. There are 40 items (5-point Likert type) and 4 dimensions: self-care maintenance, self-care monitoring, self-care management and self-care confidence.
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: Baseline and 12 weeksPre- and post-intervention measurements were conducted. Measure the change in self-perceived ability to implement health-promoting behaviours, which include subscales of Exercise, Nutrition, Responsible Health Practice, and Psychological Well-being. The scores range from 0 to 112; a higher score means a better outcome.
Outcome measures
Outcome data not reported
Adverse Events
Intervention
Control
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place