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Age Related Differences in Respiratory Immune Responses in Influenza Virus Infection

NCT06401720 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 800

Last updated 2024-05-07

No results posted yet for this study

Summary

The goal of this observational study is to understand immune responses to viral airway infection in adults, including the elderly. The main question(s) to answer is/are:

Why do some individuals acquire only asymptomatic or mild Influenza A virus (IAV) infection while others become severely ill and even succumb to the same disease?

Participants will be asked to donate samples when seeking health care for influenza-like symptoms or if hospitalized for IAV or SARS-CoV-2. Samples asked for are:

* Blood sample by venepuncture
* Blood sample by capillary sampling
* Nasopharyngeal aspirate
* Nasopharyngeal swab
* Endotracheal tube aspirate
* Nasal swab
* Nasal curette
* Breath Explor (sampling of expired air)

Researchers will compare obtained results with the same type of samples from healthy controls.

Conditions

  • Influenza A Infection
  • Influenza B Virus Infection
  • SARS CoV 2 Infection
  • RSV Infection

Sponsors & Collaborators

Principal Investigators

  • Anna Smed Sörensen, PhD · Karolinska Institutet

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-01-01
Primary Completion
2028-12-31
Completion
2030-12-31

Countries

  • Sweden

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06401720 on ClinicalTrials.gov