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Topical Insulin for Postoperative Wound Healing

NCT06400082 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 74

Last updated 2024-08-21

No results posted yet for this study

Summary

This study aimed to investigate the potential effect of applying topical insulin therapy on the management and healing of postoperative wounds in patients known with type 2 diabetes mellitus (T2DM) and in a parallel group without diabetes. Investigators also studied the effect of topical insulin therapy on the expression of e-cadherin and Ki67, as markers for cellular proliferation and wound repair. The levels of IL-6 and the H2O2-induced DNA damage product, 8-hydroxy-2'-deoxyguanosine (8-OHdG), were assessed as markers for inflammation and oxidative stress. Finally, histomorphological assessment of skin biopsies was also carried out.

Conditions

  • Wound Complication
  • Insulin Resistance, Diabetes

Interventions

DRUG

Insulin

Insulin is applied as a topical dressing for postoperative wounds and compared to the conventional povidone iodine treatment

DRUG

Povidone-Iodine

Insulin is applied as a topical dressing for postoperative wounds and compared to the conventional povidone iodine treatment

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Principal Investigators

  • Omnia Azmy Nabeh, MD · Cairo University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-16
Primary Completion
2024-10-01
Completion
2024-12-10

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06400082 on ClinicalTrials.gov