Positron Emission Tomography Study in Healthy Subjects to Determine the Relationship Between Plasma Concentration and Brain Target Occupancy of ASN51
NCT06390098 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 3
Last updated 2025-05-08
Summary
This is a phase 1, open-label, positron emission tomography (PET) study in healthy adult participants to determine the relationship between plasma concentration and brain target occupancy of ASN51 following a single oral dose.
Conditions
- Healthy Participants
Interventions
- DRUG
-
ASN51
Oral
Sponsors & Collaborators
-
Hammersmith Medicines Research Invicro
collaborator UNKNOWN -
Asceneuron S.A.
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 25 Years
- Max Age
- 55 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2021-08-09
- Primary Completion
- 2021-10-12
- Completion
- 2021-10-12
Countries
- United Kingdom
Study Locations
More Related Trials
-
Study of Uptake, Break Down and Elimination of an Investigational Drug in Healthy Volunteers
NCT00777361 ·Status: TERMINATED ·Phase: PHASE1
-
Study of ASN51 in Adults With Early Alzheimer's Disease
NCT06677203 ·Status: TERMINATED ·Phase: PHASE2
-
A Preliminary Study of 18F-AV-45 in Alzheimer's Disease and Healthy Elderly Volunteers
NCT01565291 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
A Study to Investigate the Regional Brain Kinetics of Brain Drug Transporters Using P-glycoprotein and Breast Cancer Resistance Protein Substrates and by Using the Positron Emission Tomography Ligand 11C-JNJ-63779586 in the Human Brain
NCT03089918 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluation of [18F]RO6958948 as Tracer for Positron Emission Tomography (PET) Imaging of Tau Burden in Alzheimer's Disease Participants
NCT02792179 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Two Doses of 18F-AV-45 in Alzheimer's Disease and Healthy Volunteers
NCT01565330 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of 18F-AV-45 in Alzheimer's Disease (AD) and Healthy Volunteers
NCT01565343 ·Status: COMPLETED ·Phase: PHASE1
-
Initial Investigation of [18F]P16-129 in Alzheimer's Disease Patients and Healthy Volunteers
NCT03902548 ·Status: COMPLETED ·Phase: PHASE1
-
Exploratory Evaluation of [11C]MPC6827
NCT04575727 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
A Phase II Trial of 18F-AV-45 Positron Emission Tomography (PET) Imaging in Healthy Volunteers, Patients With Mild Cognitive Impairment (MCI) and Patients With Alzheimer's Disease (AD)
NCT00702143 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Evaluate the Impact of MABT5102A on Brain Amyloid Load and Related Biomarkers in Patients With Mild to Moderate Alzheimer's Disease
NCT01397578 ·Status: COMPLETED ·Phase: PHASE2
-
Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers
NCT05395624 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Analysis of XTR006 PET Imaging in Non-cognitively Impaired Subjects, MCI Due toAD, and Mild to Moderate AD Subjects
NCT06151808 ·Status: COMPLETED ·Phase: NA
-
Evaluation of [123I] AV51 and SPECT as a Marker of Beta-amyloid Protein Deposition in Subjects With Alzheimer Disease in Comparison to Healthy Subjects
NCT00556660 ·Status: COMPLETED ·Phase: PHASE1
-
A PET Study of the Effects of p38 MAP Kinase Inhibitor, VX-745, on Amyloid Plaque Load in Alzheimer's Disease (AD)
NCT02423122 ·Status: COMPLETED ·Phase: PHASE2
-
Ultralow Dose PET Imaging of 18F-Florbetapir, 18F-Flutemetamol
NCT07012993 ·Status: RECRUITING ·Phase: PHASE2
-
Phase 1 Study Investigating Effects of HTL0009936 on Cognition and BOLD fMRI Signals in Healthy Elderly Subjects
NCT02546310 ·Status: COMPLETED ·Phase: PHASE1
-
A First in Human Study in Healthy Volunteers and in Participants With Frontotemporal Dementia With Granulin (GRN) Mutation
NCT03636204 ·Status: COMPLETED ·Phase: PHASE1
-
Exploratory and Safety Study of [F-18]W372
NCT00954369 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Positron Emission Tomography (PET) Amyloid Imaging of the Brain in Healthy Young Adult Subjects
NCT01265394 ·Status: COMPLETED ·Phase: PHASE3
-
An Open-Label Study Investigating MK-8931 in Participants With Mild and Moderate Hepatic Insufficiency (MK-8931-016)
NCT02910739 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of RO4602522 in Patients With Alzheimer Disease and in Healthy Volunteers
NCT01701089 ·Status: COMPLETED ·Phase: PHASE1
-
Study of EVP-6308 to Assess the Dose- and Concentration-dependent Displacement of [18F]MNI-659 by EVP-6308
NCT02001389 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase IIa Multi-Center Study of 18F-FDG PET, Safety, and Tolerability of AZD0530 in Mild Alzheimer's Disease
NCT02167256 ·Status: COMPLETED ·Phase: PHASE2
-
Clinical Trial In Healthy Volunteers And Health Elderly Volunteers To Evaluate The Safety, Tolerability And Blood Concentration After Single And Multiple Escalating Oral Doses Of PF-06751979.
NCT02793232 ·Status: COMPLETED ·Phase: PHASE1