Trial Outcomes & Findings for Testing New Ways to Name Antimicrobial Resistance (NCT NCT06356285)
NCT ID: NCT06356285
Last Updated: 2025-01-14
Results Overview
Evaluation of participant's attitudes towards antimicrobial resistance, related to questions within the survey that assess sentiment (including agreement that antimicrobial resistance is an urgent issue that needs to be addressed, antimicrobial resistance poses a risk to human health and antimicrobial resistance is an issue that may impact the participants own health). This was conducted using a quasi-binominal regression model using the sum of binary ratings of sub-sentiment questions as the primary outcome analysis.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
4296 participants
Primary outcome timeframe
6 weeks
Results posted on
2025-01-14
Participant Flow
Participant milestones
| Measure |
Control Arm - Antimicrobial Resistance
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "Antimicrobial Resistance" at the top.
|
Intervention Arm 1 - Superbugs
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the word "Superbugs" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
Intervention Arm 2 - Antibiotic Resistance
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "Antibiotic Resistance" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
Intervention Arm 3 - Antibiotic Crisis
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "The Antibiotic Crisis" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
|---|---|---|---|---|
|
Overall Study
STARTED
|
1055
|
1113
|
1092
|
1036
|
|
Overall Study
COMPLETED
|
1055
|
1113
|
1092
|
1036
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Testing New Ways to Name Antimicrobial Resistance
Baseline characteristics by cohort
| Measure |
Control Arm - Antimicrobial Resistance
n=1055 Participants
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "Antimicrobial Resistance" at the top.
|
Intervention Arm 1 - Superbugs
n=1113 Participants
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the word "Superbugs" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
Intervention Arm 2 - Antibiotic Resistance
n=1092 Participants
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "Antibiotic Resistance" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
Intervention Arm 3 - Antibiotic Crisis
n=1036 Participants
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "The Antibiotic Crisis" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
Total
n=4296 Participants
Total of all reporting groups
|
|---|---|---|---|---|---|
|
Age, Customized
18-24
|
121 Participants
n=99 Participants
|
129 Participants
n=107 Participants
|
114 Participants
n=206 Participants
|
123 Participants
n=7 Participants
|
487 Participants
n=31 Participants
|
|
Age, Customized
25-39
|
279 Participants
n=99 Participants
|
281 Participants
n=107 Participants
|
272 Participants
n=206 Participants
|
258 Participants
n=7 Participants
|
1090 Participants
n=31 Participants
|
|
Age, Customized
40-54
|
283 Participants
n=99 Participants
|
304 Participants
n=107 Participants
|
295 Participants
n=206 Participants
|
296 Participants
n=7 Participants
|
1178 Participants
n=31 Participants
|
|
Age, Customized
55+
|
372 Participants
n=99 Participants
|
399 Participants
n=107 Participants
|
411 Participants
n=206 Participants
|
359 Participants
n=7 Participants
|
1541 Participants
n=31 Participants
|
|
Sex/Gender, Customized
Male
|
565 Participants
n=99 Participants
|
580 Participants
n=107 Participants
|
541 Participants
n=206 Participants
|
538 Participants
n=7 Participants
|
2224 Participants
n=31 Participants
|
|
Sex/Gender, Customized
Female
|
487 Participants
n=99 Participants
|
526 Participants
n=107 Participants
|
543 Participants
n=206 Participants
|
494 Participants
n=7 Participants
|
2050 Participants
n=31 Participants
|
|
Sex/Gender, Customized
Other
|
3 Participants
n=99 Participants
|
7 Participants
n=107 Participants
|
8 Participants
n=206 Participants
|
4 Participants
n=7 Participants
|
22 Participants
n=31 Participants
|
|
Race/Ethnicity, Customized
Asian
|
93 Participants
n=99 Participants
|
98 Participants
n=107 Participants
|
75 Participants
n=206 Participants
|
84 Participants
n=7 Participants
|
350 Participants
n=31 Participants
|
|
Race/Ethnicity, Customized
Black
|
31 Participants
n=99 Participants
|
31 Participants
n=107 Participants
|
39 Participants
n=206 Participants
|
24 Participants
n=7 Participants
|
125 Participants
n=31 Participants
|
|
Race/Ethnicity, Customized
Mixed / Other
|
39 Participants
n=99 Participants
|
55 Participants
n=107 Participants
|
38 Participants
n=206 Participants
|
45 Participants
n=7 Participants
|
177 Participants
n=31 Participants
|
|
Race/Ethnicity, Customized
White
|
892 Participants
n=99 Participants
|
929 Participants
n=107 Participants
|
940 Participants
n=206 Participants
|
883 Participants
n=7 Participants
|
3644 Participants
n=31 Participants
|
|
Region of Enrollment
United Kingdom
|
1055 participants
n=99 Participants
|
1113 participants
n=107 Participants
|
1092 participants
n=206 Participants
|
1036 participants
n=7 Participants
|
4296 participants
n=31 Participants
|
PRIMARY outcome
Timeframe: 6 weeksPopulation: All adults (over the age of 18, representative of the UK population) who responded to the survey question.
Evaluation of participant's attitudes towards antimicrobial resistance, related to questions within the survey that assess sentiment (including agreement that antimicrobial resistance is an urgent issue that needs to be addressed, antimicrobial resistance poses a risk to human health and antimicrobial resistance is an issue that may impact the participants own health). This was conducted using a quasi-binominal regression model using the sum of binary ratings of sub-sentiment questions as the primary outcome analysis.
Outcome measures
| Measure |
Control Arm - Antimicrobial Resistance
n=1055 Survey Answers (One per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "Antimicrobial Resistance" at the top.
|
Intervention Arm 1 - Superbugs
n=1113 Survey Answers (One per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the word "Superbugs" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
Intervention Arm 2 - Antibiotic Resistance
n=1092 Survey Answers (One per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "Antibiotic Resistance" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
Intervention Arm 3 - Antibiotic Crisis
n=1036 Survey Answers (One per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "The Antibiotic Crisis" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
|---|---|---|---|---|
|
Percentage of Correct Answers by Participants on Questions Designed to Evaluate Attitudes Towards Antimicrobial Resistance (Sentiment)
|
81 percentage of correct answers
|
83.2 percentage of correct answers
|
86.3 percentage of correct answers
|
85.2 percentage of correct answers
|
SECONDARY outcome
Timeframe: 6 weeksPopulation: Adults residing in the UK aged over 18, passed attention check
Comprehension of the meaning of Antimicrobial Resistance, related to questions within the survey that evaluate comprehension (what has caused antimicrobial resistance, what is the solution to antimicrobial resistance, what antimicrobial resistance is). This was conducted using a quasi-binominal regression model using the number of correct answers to comprehension questions.
Outcome measures
| Measure |
Control Arm - Antimicrobial Resistance
n=1055 Survey Answers (one per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "Antimicrobial Resistance" at the top.
|
Intervention Arm 1 - Superbugs
n=1113 Survey Answers (one per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the word "Superbugs" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
Intervention Arm 2 - Antibiotic Resistance
n=1092 Survey Answers (one per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "Antibiotic Resistance" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
Intervention Arm 3 - Antibiotic Crisis
n=1036 Survey Answers (one per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "The Antibiotic Crisis" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
|---|---|---|---|---|
|
Percentage of Correct Answers by Participants on Questions Designed to Evaluate Comprehension of Antimicrobial Resistance
|
63.3 Percentage of correct answers
|
65.1 Percentage of correct answers
|
66.0 Percentage of correct answers
|
65.4 Percentage of correct answers
|
SECONDARY outcome
Timeframe: 6 weeksPopulation: Adults residing in the UK aged over 18, passed attention check
Intention regarding antibiotic use in the context of antimicrobial resistance related to questions within the survey that evaluate intent - asking participants about whether they would request antibiotics in certain scenarios. This was conducted using a separate logistic regression for each scenario (binary - Yes or No).
Outcome measures
| Measure |
Control Arm - Antimicrobial Resistance
n=1055 Survey Answers (One per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "Antimicrobial Resistance" at the top.
|
Intervention Arm 1 - Superbugs
n=1113 Survey Answers (One per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the word "Superbugs" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
Intervention Arm 2 - Antibiotic Resistance
n=1092 Survey Answers (One per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "Antibiotic Resistance" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
Intervention Arm 3 - Antibiotic Crisis
n=1036 Survey Answers (One per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "The Antibiotic Crisis" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
|---|---|---|---|---|
|
Percentage of Participants Who Stated They Would Request Antibiotics
|
8.7 Percentage of participants
|
8.5 Percentage of participants
|
8.8 Percentage of participants
|
8.4 Percentage of participants
|
SECONDARY outcome
Timeframe: 6 weeksPopulation: Adults residing in the UK aged over 18, passed attention check
Recall of the term used to describe antimicrobial resistance in the intervention. This was conducted using a separate logistic regression for each question (asking about recall of the name at the top of the poster and the content of the poster) (binary - Yes or No).
Outcome measures
| Measure |
Control Arm - Antimicrobial Resistance
n=1055 Survey Answers (One per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "Antimicrobial Resistance" at the top.
|
Intervention Arm 1 - Superbugs
n=1113 Survey Answers (One per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the word "Superbugs" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
Intervention Arm 2 - Antibiotic Resistance
n=1092 Survey Answers (One per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "Antibiotic Resistance" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
Intervention Arm 3 - Antibiotic Crisis
n=1036 Survey Answers (One per participant)
Participants will be shown an image of a poster at a bus stop. This will contain information about antibiotics, and will have the words "The Antibiotic Crisis" at the top.
Presentation of Antimicrobial Resistance: Participants will be presented with a poster containing information about antibiotics, each intervention poster will have a different name at the top, representing a new way to frame antimicrobial resistance.
|
|---|---|---|---|---|
|
Percentage of Participants Who Correctly Recalled the Terminology Related to Antimicrobial Resistance
|
72 Percentage of participants
|
65.4 Percentage of participants
|
79 Percentage of participants
|
74.5 Percentage of participants
|
Adverse Events
Control Arm - Antimicrobial Resistance
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Intervention Arm 1 - Superbugs
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Intervention Arm 2 - Antibiotic Resistance
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Intervention Arm 3 - Antibiotic Crisis
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place