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Efficacy of N-acetylcysteine in Preventing Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients.

NCT06354712 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2025-01-15

No results posted yet for this study

Summary

A prospective, randomized, controlled, parallel clinical trial will be conducted at Clinical Oncology and Nuclear Medicine Center at Mansoura University Hospital to assess the efficacy of N-acetylcysteine in the prevention of radiotherapy induced oral mucositis in Head and Neck cancer patients.

Conditions

  • Oral Mucositis (Ulcerative) Due to Radiation

Interventions

DRUG

N-Acetyl-Cysteine with Institutional standard care

A potent antioxidant and anti-inflammatory drug (A precursor of the endogenous antioxidant glutathione)

DRUG

Institutional standard care

Benzydamine Mouthwash

Sponsors & Collaborators

  • Mansoura University

    lead OTHER

Principal Investigators

  • Mohamed el-Husseiny shams, Professor · Department of Clinical pharmacy and Pharmacy practice, Faculty of Pharmacy, Mansoura University

  • Noha Mansour, phD · Department of Clinical pharmacy and Pharmacy practice, Faculty of Pharmacy, Mansoura University

  • Rasha Mohamed Abd-Ellatif, Professor · Center of Clinical Oncology and nuclear medicine, Faculty of Medicine, Mansoura University

  • Fatma Gharib Khirallah, Associate Professor · Center of Clinical Oncology and nuclear medicine, Faculty of Medicine, Tanta University

  • Mohamed Awad Ebrahim, Professor · Center of Medical Oncology and Adult BMT, Faculty of Medicine, Mansoura University.

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-04-04
Primary Completion
2025-03-01
Completion
2025-03-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06354712 on ClinicalTrials.gov