Prophylactic Properties of Carrot Juice in Patients With High-Risk Colorectal Polyps

Summary

The goal of this prospective randomized double-blinded bi-national study is to test the prophylactic effect of polyacetylenes from carrots on the population of patients who had a resection of high-risk adenomas of the large bowel.

The main question it aims to answer is: Will carrot juice rich in polyacetylenes inhibit neoplastic transformation and growth in high-risk humans?

Participants will have to drink 100 ml of juice daily after the adenoma resection for 1 year and keep a simple diary/calendar.

Researchers will compare the group with ingestion of Falcarinol (FaOH) / Falcarindiol (FaDOH) rich carrot juice versus the group consuming placebo juice, to see if the polyacetylenes significantly reduces neoplastic transformation and growth in high-risk patients.

Conditions

• Colorectal Cancer Prevention

Interventions

DIETARY_SUPPLEMENT

Carrot juice from Yellowstone carrots cultivars

Consumption of 100 ml of carrot juice daily for 1 year

DIETARY_SUPPLEMENT

Placebo juice

Consumption of 100 ml of placebo juice daily for 1 year

Sponsors & Collaborators

• Karolinska Institutet

  collaborator OTHER

• Umeå University

  collaborator OTHER

• Uppsala University Hospital

  collaborator OTHER

• Svendborg Hospital

  collaborator OTHER

• Ersta Hospital, Sweden

  collaborator OTHER

• St Goran's Hospital

  collaborator OTHER

• Sahlgrenska University Hospital

  collaborator OTHER

• Odense University Hospital

  lead OTHER

Principal Investigators

• Gunnar Baatrup, Professor · OUH og Svendborg Sygehus

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-06-20

Primary Completion

2027-06-01

Completion

2027-12-01

Countries

• Denmark

Study Locations