Doxycycline in Type II Diabetes
NCT06329882 · Status: RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 60
Last updated 2025-04-04
Summary
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by hyperglycemia, weight loss, and cardio-metabolic complications. T2DM develops due to the progression of insulin resistance (IR), impairment of insulin insensitivity, and failure of the pancreatic β-cells to release sufficient amount of insulin in response to glucose burden
Conditions
- Diabetes Mellitus, Type 2
Interventions
- DRUG
-
Sitagliptin 100mg
Sitagliptin is used along with diet and exercise and sometimes with other medications to lower blood sugar levels in adults with type 2 diabetes
- DRUG
-
Doxycyclin
Doxycycline belongs to the class of medicines known as tetracycline antibiotics. It works by killing bacteria or preventing their growth.
Sponsors & Collaborators
-
Mostafa Bahaa
lead OTHER
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 40 Years
- Max Age
- 60 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-03-30
- Primary Completion
- 2026-03-20
- Completion
- 2026-04-20
Countries
- Egypt
Study Locations
More Related Trials
-
A Study Comparing the Pharmacokinetic and Pharmacodynamic Profiles for Sitagliptin, Saxagliptin and Vildagliptin in Participants With Type 2 Diabetes Mellitus (T2DM) (MK-0431-142)
NCT01582308 ·Status: COMPLETED ·Phase: PHASE1
-
Study of the Effect of Sitagliptin on Glucose (Sugar) Metabolism in Patients With Heart Failure
NCT00657280 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Sitagliptin and Glucagon Counterregulation
NCT02256189 ·Status: COMPLETED ·Phase: PHASE4
-
Effects of Sitagliptin in Individuals With Genetically Decreased DPP4
NCT04323189 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE4
-
Sitagliptin Metformin Add-on Study in Patients With Type 2 Diabetes Mellitus
NCT00337610 ·Status: COMPLETED ·Phase: PHASE3
-
Study to Assess the Efficacy and Safety of Sitagliptin in Recently Diagnosed, Naive Type 2 Diabetics With Inadequate Glycemic Control on Diet and Exercise (0431-158)
NCT00832390 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Add-on SGLT2i, TZD, or Combination Therapy in Type 2 Diabetes Patients on DPP4 Inhibitors
NCT07108985 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
Comparison of the Effect of Exenatide Versus Sitagliptin on 24-hour Average Glucose in Patients With Type 2 Diabetes on Metformin or a Thiazolidinedione
NCT00729326 ·Status: COMPLETED ·Phase: PHASE4
-
Sitagliptin for the Treatment of Type 2 Diabetes
NCT04495881 ·Status: UNKNOWN ·Phase: PHASE4
-
An Investigational Drug in Patients With Type 2 Diabetes Mellitus and Chronic Renal Insufficiency (0431-028)(COMPLETED)
NCT00095056 ·Status: COMPLETED ·Phase: PHASE3
-
Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of MBX-2982 Administered Daily for 4 Weeks as Monotherapy in Patients With Type 2 Diabetes
NCT01035879 ·Status: COMPLETED ·Phase: PHASE2
-
The Effect of Linagliptin (BI 1356) on 24h-glucose Control and Various Biomarkers in Type 2 Diabetic Patients
NCT00716092 ·Status: COMPLETED ·Phase: PHASE2
-
The Impact of Clinical Pharmacist Intervention and Dapagliflozin as Add-On Therapy in the Management of Type 2 Diabetes Mellitus.
NCT06719661 ·Status: COMPLETED ·Phase: NA
-
A Study of an Investigational Drug Sitagliptin for Type 2 Diabetes Mellitus (0431-044)
NCT00127192 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of TAK-875 in Combination With Sitagliptin in Participants With Type 2 Diabetes Mellitus
NCT01414920 ·Status: COMPLETED ·Phase: PHASE2
-
30-Week Extension to an Initial Combination Study (24 Weeks in Duration) of Sitagliptin With Pioglitazone (0431-064)
NCT01028391 ·Status: COMPLETED ·Phase: PHASE3
-
Risk of Acute Liver Failure Among Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatments
NCT01086293 ·Status: COMPLETED
-
To Assess Safety of Fixed Dose Combination of Dapagliflozin and Saxagliptin in Type 2 Diabetes Mellitus Patients
NCT04445714 ·Status: COMPLETED ·Phase: PHASE4
-
Treatment With Sitagliptin in Non-obese Japanese Patients With Type 2 Diabetes Mellitus
NCT01642108 ·Status: UNKNOWN ·Phase: NA
-
Comparison Between GLP 1 Analogues and DPP 4 Inhibitors in Type 1 Diabetes Mellitus
NCT01235819 ·Status: COMPLETED ·Phase: PHASE4
-
Mechanisms of Glucose Lowering Effects of Sitagliptin and Metformin Alone and in Combination in Patients With T2DM
NCT00820573 ·Status: COMPLETED ·Phase: PHASE4
-
Sitagliptin Dose Comparison Study in Patients With Type 2 Diabetes (MK-0431-077)(COMPLETED)
NCT00541229 ·Status: COMPLETED ·Phase: PHASE1
-
A Multi-Center, Randomized, Double-Blind, Phase III Trial to Evaluate the Safety and Efficacy of Saxagliptin Co-administered With Dapagliflozin Compared to Saxagliptin or Dapagliflozin All Given as add-on Therapy to Metformin in Subject With Type 2 Diabetes
NCT02681094 ·Status: COMPLETED ·Phase: PHASE3
-
Effect of Sitagliptin on Polycystic Ovarian Syndrome Patients
NCT05972928 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
Study of Safety and Efficacy of PF-04991532 in Subjects With Type 2 Diabetes
NCT01338870 ·Status: COMPLETED ·Phase: PHASE2