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PERSonalized rObotic NeurorehAbilitation for Stroke Survivors

NCT06312540 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2025-06-06

No results posted yet for this study

Summary

The aim is to carry out a first clinical study, to expand existing knowledge about the neurophysiological mechanisms underlying post-stroke recovery. The information acquired during this phase will be used as building blocks to develop customized protocols. Understanding the mechanisms underlying stroke-induced motor deficits and motor recovery is mandatory to improve clinicians; ability to guide the repair of the affected neural structures. The motor system comprises a network of cortical and subcortical areas interacting via excitatory and inhibitory circuits, thereby governing motor behaviour. Stroke lesions cause neural dysfunction both at the lesion site and in remote brain regions. Abnormal interactions among cortical regions within the motor network contribute to the motor impairment after stroke. Longitudinal analysis of neural activity and connectivity can help to understand the pathophysiology mechanisms underlying functional impairment and recovery after stroke. Analysis of the data will try to extract biomarkers of plasticity and recovery that will be used to design customized therapeutic interventions.

Conditions

  • Stroke Acute

Sponsors & Collaborators

  • Fondazione Don Carlo Gnocchi Onlus

    collaborator OTHER

  • Scuola Superiore Sant'Anna di Pisa

    collaborator OTHER

  • Azienda Ospedaliero, Universitaria Pisana

    lead OTHER

Principal Investigators

  • Carmelo Chisari, Medical · Azienda Ospedaliero, Universitaria Pisana

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-09-02
Primary Completion
2024-09-01
Completion
2024-09-01

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06312540 on ClinicalTrials.gov