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Understanding Risk Factors for Progressive Chronic Kidney Disease in Malawi

NCT06312072 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1100

Last updated 2024-03-15

No results posted yet for this study

Summary

Worldwide, the number of people living with long-term health conditions, including chronic kidney disease (CKD), is increasing. CKD is usually asymptomatic in early stages but can progress to advanced disease, including kidney failure, causing significant morbidity and mortality.

In low-income countries of sub-Saharan Africa, including Malawi, treatments for kidney failure are not yet widely available and are prohibitively expensive . It is therefore vital to:

(a) Prevent development of CKD in the first place (b) Detect CKD earlier so that more cost-effective treatments can be given to slow progression.

There is little evidence on factors that drive CKD progression in Malawi, or on interventions that may be cost-effective for improving detection and slowing disease progression in this setting. This PhD will address these knowledge gaps, through the following aims:

1\) Determine the mortality associated with CKD, and the risk factors driving its development and progression in Malawian adults 2) Investigate the impacts of different models for integrating screening and prevention strategies for CKD and its risk factors into health services for other long-term conditions in low- and middle-income countries 3) With patients, carers, healthcare workers and policy makers, evaluate the feasibility and acceptability of different potential models for integrating CKD screening and prevention strategies into health services for high-risk patient groups in Malawi

Conditions

  • Chronic Kidney Diseases
  • Non-Communicable Chronic Diseases
  • Non-communicable Disease
  • Kidney Diseases

Interventions

OTHER

No intervention; observational study

No intervention; observational study

Sponsors & Collaborators

  • Wellcome Trust

    collaborator OTHER

  • Malawi Epidemiology and Intervention Research Unit

    collaborator OTHER

  • London School of Hygiene and Tropical Medicine

    collaborator OTHER

  • University of Glasgow

    collaborator OTHER

  • Malawi-Liverpool-Wellcome Trust Clinical Research Programme

    collaborator OTHER

  • Liverpool School of Tropical Medicine

    lead OTHER

Principal Investigators

  • Charlotte Snead, BM BCh · Liverpool School of Tropical Medicine

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-02-14
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • Malawi

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06312072 on ClinicalTrials.gov