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Uganda Sickle Surveillance Study (US-3)

NCT06301893 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1000000

Last updated 2025-06-13

No results posted yet for this study

Summary

It is estimated that over 250,000 babies are born with sickle cell disease (SCD) annually in sub-Saharan Africa, and only 10% - 50% of them survive beyond five years of age. Data describing the magnitude of the sickle cell problem are lacking in most African countries. The available data on prevalence were mainly from older studies and small numbers of hospitalized patients. In Uganda, approximately 25,000 children are born with SCD but 70-80% die before their 5th birthday. Lehmann and Raper found 'sicklaemia' prevalence of 0.8% and 45% in the Sebei and Bambaa ethnic groups, respectively. A recent study found a SCT and SCD prevalence of 3% - 19% and 0% - 3%, respectively but this study addressed only 5 of Uganda's 111 districts and used a small convenience sample of children aged 6 - 60 months. The objective of this study is to determine the prevalence and map out the burden of SCT and SCD in Uganda.

Conditions

Sponsors & Collaborators

  • Makerere University

    collaborator OTHER

  • Ministry of Health, Uganda

    collaborator OTHER_GOV

  • Mulago Hospital, Uganda

    collaborator OTHER

  • Children's Hospital Medical Center, Cincinnati

    lead OTHER

Principal Investigators

  • Russell Ware, MD, PhD · Children's Hospital Medical Center, Cincinnati

  • Grace Ndeezi, MBChB, MMed, PhD · Department of Pediatrics & Child Health College of Health Sciences Makerere University

Eligibility

Max Age
12 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-09-07
Primary Completion
2030-12-31
Completion
2032-12-31

Countries

  • Uganda

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06301893 on ClinicalTrials.gov