Obinutuzumab in Treatment of Fibrillary Glomerulonephritis
NCT06295770 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 20
Last updated 2026-04-13
Summary
The purpose of this research is to learn if Obinutuzumab is effective and safe in treating patients with fibrillary glomerulonephritis (FGN).
Conditions
- Fibrillary Glomerulonephritis
Interventions
- DRUG
-
Obinutuzumab 1g IV on day one and 1 g IV on day 15, followed by identical course at month 6.
Sponsors & Collaborators
- lead OTHER
Principal Investigators
-
Ladan Zand · Mayo Clinic
-
Fernando Fervenza, MD · Mayo Clinic
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-06-24
- Primary Completion
- 2026-12-31
- Completion
- 2026-12-31
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Daratumumab in Treatment of PGNMID and C3 GN
NCT03095118 ·Status: COMPLETED ·Phase: PHASE2
-
Obinutuzumab in the Management of Idiopathic Membranous Nephropathy
NCT05845762 ·Status: UNKNOWN
-
A Study to Examine the Efficacy and Safety of Zanubrutinib Given to Adults With Primary Membranous Nephropathy
NCT05707377 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2/PHASE3
-
Study of FG-4592 in Subjects With Chronic Kidney Disease in China
NCT01599507 ·Status: COMPLETED ·Phase: PHASE2
-
Daratumumab for Treatment of Proliferative Glomerulonephritis With Monoclonal Immune Deposits
NCT05654506 ·Status: RECRUITING ·Phase: PHASE2
-
A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy
NCT04629248 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
An Outcome Analysis of Primary Membranous Nephropathy
NCT06242327 ·Status: RECRUITING
-
A Study to Evaluate the Efficacy and Safety of Obinutuzumab Versus MMF in Participants With Childhood Onset Idiopathic Nephrotic Syndrome
NCT05627557 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Rituximab in the Treatment of Idiopathic Membranous Nephropathy
NCT00405340 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of KP104 to Treat Glomerulonephritis
NCT05517980 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Safety and Pharmacokinetics of FG-3019 in Adolescents and Adults With Focal Segmental Glomerulosclerosis (FSGS)
NCT00782561 ·Status: TERMINATED ·Phase: PHASE1
-
A Randomized Study of the Safety and Efficacy of FG-2216 in Subjects With Renal Anemia Not Requiring Dialysis and Not Receiving Recombinant Human Erythropoietin
NCT00456053 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)
NCT06291376 ·Status: RECRUITING ·Phase: PHASE3
-
Study of GBT021601 in Participants With Renal Impairment
NCT05878704 ·Status: TERMINATED ·Phase: PHASE1
-
Fingolimod for the Abrogation of Interstitial Fibrosis and Tubular Atrophy Following Kidney Transplantation
NCT05285878 ·Status: ENROLLING_BY_INVITATION ·Phase: PHASE2
-
Study of the Clinical Efficacy and Safety of Finerenone for the Treatment of IGA Nephropathy
NCT06460987 ·Status: COMPLETED
-
A Study of Obinutuzumab to Evaluate Safety and Tolerability in Hypersensitized Adult Participants With End Stage Renal Disease Awaiting Transplantation
NCT02586051 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy of Rituximab in Comparison to Continued Corticosteroid Treatment in Idiopathic Nephrotic Syndrome
NCT03298698 ·Status: UNKNOWN ·Phase: PHASE3
-
Evaluate Rituximab Treatment for Idiopathic Membranous Nephropathy
NCT01508468 ·Status: COMPLETED ·Phase: PHASE3
-
Pirfenidone to Treat Kidney Disease (Focal Segmental Glomerulosclerosis)
NCT00001959 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Randomized, Open-label, Multicenter Clinical Study Evaluating the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of SHR-2173 Injection in Patients With Primary Membranous Nephropathy
NCT07289763 ·Status: RECRUITING ·Phase: PHASE2
-
Efficacy and Safety of SHR-2010 Injection in the Treatment of Primary IgA Nephropathy
NCT05847920 ·Status: TERMINATED ·Phase: PHASE2
-
Trial to Assess Safety and Efficacy of MOR202 in Anti-PLA2R + Membranous Nephropathy (aMN)
NCT04145440 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease
NCT06500702 ·Status: RECRUITING ·Phase: PHASE2
-
Finerenone in Patients With IgA-nephropathy: Prospective Interventional Trial
NCT07056595 ·Status: RECRUITING ·Phase: NA