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Intraoperative Imaging of Lymph Nodes

NCT06276439 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 48

Last updated 2024-02-26

No results posted yet for this study

Summary

One-third of the global population battles cancer, with surgery being the primary treatment for localized forms. Successful treatment often hinges on the thorough removal of primary tumors and pinpointing cancerous sentinel lymph nodes (SLN). Although modern surgical imaging and fluorescent probes enhance the detection of sentinel lymph nodes using near-infrared (NIR) fluorescence, their inability to precisely determine the nodes' status can result in additional surgeries, lymphedema, and a reduced quality of life for patients. Our research direction aims to harness the potential of bioinspired imaging technologies with the goal of precisely identifying SLN status and ensuring only the cancerous lymph nodes are excised during the initial procedure. To realize this objective, we're drawing inspiration from the mantis shrimp's visual system to create a single-chip multispectral camera that spans the deep ultraviolet to the near-infrared spectrum. Our pioneering sensor seamlessly combines perovskite nanocrystals, optical filters, and vertically-aligned photodetectors on a single chip, enabling concurrent imaging of external NIR fluorophores and internal UV fluorescence from tumor-specific markers.

Conditions

Interventions

PROCEDURE

Surgical removal of breast cancer and lymph nodes

The patients will undergo a surgical procedure to remove tumor tissue in the breast and its associated lymph nodes. No clinical decision is based on the imaging device tested.

Sponsors & Collaborators

  • U.S. National Science Foundation

    collaborator FED

  • Ss. Cyril and Methodius University of Skopje, Macedonia

    collaborator UNKNOWN

  • University of Illinois at Urbana-Champaign

    lead OTHER

Principal Investigators

  • Viktor Gruev, PhD · University of Illinois Urbana Champaign

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-02-19
Primary Completion
2025-03-30
Completion
2026-02-19

Countries

  • North Macedonia

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06276439 on ClinicalTrials.gov