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HONEY for the Treatment of POst-Tonsillectomy Pain

NCT06275698 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2025-04-29

No results posted yet for this study

Summary

Double-blind, randomised, placebo controlled, single-site trial in adults to compare the effect of Manuka honey with standard of care compared to placebo with standard of care on post-tonsillectomy pain and postoperative outcomes.

Main aim is to investigate a potential improvement in post-tonsillectomy pain control, with a low cost and freely available alternative to conventional analgesics. Recent systematic review and multidisciplinary consensus suggest a potential role for the inclusion of honey for this purpose. Clinical efficacy over placebo remains to be conclusively demonstrated in robust clinical trials.

Conditions

  • Post Surgical Pain
  • Analgesia

Interventions

DIETARY_SUPPLEMENT

Manuka honey MGO 1000

Natural Manuka honey, produced in New Zealand. With MGO content ≥ 1000.

DIETARY_SUPPLEMENT

Sugar-based syrup, thickened with sodium alginate and flavoured with honey flavouring

Sugar-based syrup, thickened with sodium alginate and flavoured with honey flavouring, 15ml, three times a day, for 14 days. To be kept on the tongue for at least 10 seconds prior to swallowing.

Sponsors & Collaborators

  • Manuka Doctor UK Ltd

    collaborator UNKNOWN

  • National Institute for Health Research, United Kingdom

    collaborator OTHER_GOV

  • East and North Hertfordshire NHS Trust

    lead OTHER_GOV

Principal Investigators

  • Phillip Smith, PhD · East and North Hertfordshire NHS Trust

  • George Mochloulis, MD · East and North Hertfordshire NHS Trust

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-09-04
Primary Completion
2025-09-04
Completion
2025-09-04

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06275698 on ClinicalTrials.gov