Trial Outcomes & Findings for InformationSeekingMesolimbicEngagementStudy1 (NCT NCT06257446)
NCT ID: NCT06257446
Last Updated: 2026-04-23
Results Overview
Functional Magnetic Resonance Imaging Activation characterizing mesolimbic-hippocampal interactions as queried using representational simliarity analysis across these two regions of interest. In this analysis, we explore the pattern similarity within the same set of regions (mesolimbic and hippocampal regions) across different trial types. In this way the standard unit for these values reflect a correlation that is summarized by a standardized beta-value extracted from a nested mixed effects model.
COMPLETED
NA
76 participants
During Procedure
2026-04-23
Participant Flow
Recruitment Status: Completed Study Start Date: October 25, 2023 Primary Completion Date: February 09, 2024 Study Completion Date: February 09, 2024 Enrollment (Actual): 76 participants Study Locations: Temple University, Philadelphia, PA, United States
Of the 76 participants that were recruiteted, 0 were excluded prior to assignment.
Participant milestones
| Measure |
Motivation
Trials in which participants are motivated by agency or not in a within-subjects design
Task Instructions: Participants will be given cued instructions as to whether they are in a high or low motivation condition
|
|---|---|
|
Overall Study
STARTED
|
76
|
|
Overall Study
COMPLETED
|
76
|
|
Overall Study
NOT COMPLETED
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
InformationSeekingMesolimbicEngagementStudy1
Baseline characteristics by cohort
| Measure |
Motivation
n=76 Participants
Trials in which participants are motivated by agency or not in a within-subjects design
Task Instructions: Participants will be given cued instructions as to whether they are in a high or low motivation condition
|
|---|---|
|
Age, Categorical
<=18 years
|
0 Participants
n=60 Participants
|
|
Age, Categorical
Between 18 and 65 years
|
76 Participants
n=60 Participants
|
|
Age, Categorical
>=65 years
|
0 Participants
n=60 Participants
|
|
Sex: Female, Male
Female
|
46 Participants
n=60 Participants
|
|
Sex: Female, Male
Male
|
30 Participants
n=60 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=60 Participants
|
|
Race (NIH/OMB)
Asian
|
12 Participants
n=60 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=60 Participants
|
|
Race (NIH/OMB)
Black or African American
|
10 Participants
n=60 Participants
|
|
Race (NIH/OMB)
White
|
51 Participants
n=60 Participants
|
|
Race (NIH/OMB)
More than one race
|
3 Participants
n=60 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=60 Participants
|
|
Region of Enrollment
United States
|
76 participants
n=60 Participants
|
PRIMARY outcome
Timeframe: During ProcedurePopulation: This is the entire population that continued the protocol. While in typical clinical trials there may be a comparison across arms of a group, this study utilized a within-subjects design, thus we were comparing conditions within one group of participants. In this way, our overall participant pool reflects a single arm and our statistical comparisons were made across conditions within this single group.
Functional Magnetic Resonance Imaging Activation characterizing mesolimbic-hippocampal interactions as queried using representational simliarity analysis across these two regions of interest. In this analysis, we explore the pattern similarity within the same set of regions (mesolimbic and hippocampal regions) across different trial types. In this way the standard unit for these values reflect a correlation that is summarized by a standardized beta-value extracted from a nested mixed effects model.
Outcome measures
| Measure |
Motivation
n=76 Participants
Trials in which participants are motivated by agency or not in a within-subjects design
Task Instructions: Participants will be given cued instructions as to whether they are in a high or low motivation condition
|
|---|---|
|
Mesolimbic-hippocampal Interactions
high motivation
|
.153 standardized beta-value
Standard Error 0.0008
|
|
Mesolimbic-hippocampal Interactions
low motivation
|
.150 standardized beta-value
Standard Error 0.0017
|
PRIMARY outcome
Timeframe: 24-hours, we administered our memory test 24 hours after the first session but this is the first time we are administering this test.Population: This is the entire population that continued the protocol. While in typical clinical trials there may be a comparison across arms of a group, this study utilized a within-subjects design, thus we were comparing conditions within one group of participants. In this way, our overall participant pool reflects a single arm and our statistical comparisons were made across conditions within this single group.
Item and Associative memory for memoranda shown during the task. This measure reflects the percent of memory test retrieval trials in which participants were able to successfull remember an item and its associated features compared across a high and low reward condition.
Outcome measures
| Measure |
Motivation
n=76 Participants
Trials in which participants are motivated by agency or not in a within-subjects design
Task Instructions: Participants will be given cued instructions as to whether they are in a high or low motivation condition
|
|---|---|
|
Episodic Memory
Low Reward
|
.751 Proportion of Trials Correct
Standard Error .029
|
|
Episodic Memory
High Reward
|
.75 Proportion of Trials Correct
Standard Error .028
|
Adverse Events
Motivation
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place