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A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation

NCT06234969 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2025-10-30

No results posted yet for this study

Summary

This study will be the first of its kind to explore the impact of continuous theta burst stimulation (cTBS) to the intraparietal sulcus (IPS) on arousal symptoms among patients with posttraumatic stress disorder (PTSD). The investigators will demonstrate that IPS cTBS results in significant reduction in arousal (measured by startle response) compared to sham cTBS, that IPS cTBS interacts with extinction training to further improve arousal, and that there is a dose/response effect of cTBS on arousal. The investigators will also demonstrate that IPS cTBS significantly improves retention of extinction learning, the experimental analogue of exposure therapy.

Conditions

Interventions

DEVICE

Continuous Theta Burst Stimulation to the Intraparietal Sulcus

Continuous Theta Burst Stimulation delivered to the Intraparietal Sulcus

DEVICE

Sham Continuous Theta Burst Stimulation

Sham Continuous Theta Burst Stimulation

Sponsors & Collaborators

Principal Investigators

  • Lily A Brown, PhD · University of Pennsylvania

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-04-29
Primary Completion
2028-07-31
Completion
2028-10-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06234969 on ClinicalTrials.gov