Trial Outcomes & Findings for Feasibility Trial Using an Inpatient Insulin Dosing Calculator (NCT NCT06206525)

NCT ID: NCT06206525

Last Updated: 2026-05-11

Results Overview

Participates developed blood glucose concentration lower than 54 mg/dL

Recruitment status

COMPLETED

Study phase

Target enrollment

38 participants

Primary outcome timeframe

During the first 48 hours after admission

Results posted on

2026-05-11

Participant Flow

Participants were recruited by PI: Hou-Hsien Chiang at University of Washington - Montlake, Harborview and Northwest hospitals from March 2024 to May 2025.

The observational cohort arm was historical 140 participants, and therefore, were not included in the enrollment number.

Participant milestones

Participant milestones
Measure	Initial Insulin Dosing Calculator Participants received initial insulin doses by the calculator on hospital admission	Observational Cohort Historical patients who received initial insulin doses by standard of care
Overall Study STARTED	38	140
Overall Study COMPLETED	38	140
Overall Study NOT COMPLETED	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Initial Insulin Dosing Calculator n=38 Participants Participants received initial insulin doses by the calculator on hospital admission	Observational Cohort n=140 Participants Historical patients who received initial insulin doses by standard of care	Total n=178 Participants Total of all reporting groups
Age, Continuous	63.1 year n=38 Participants	63.6 year n=140 Participants	63.6 year n=178 Participants
Sex: Female, Male Female	14 Participants n=38 Participants	60 Participants n=140 Participants	74 Participants n=178 Participants
Sex: Female, Male Male	24 Participants n=38 Participants	80 Participants n=140 Participants	104 Participants n=178 Participants
Race and Ethnicity Not Collected	—	—	0 Participants Race and Ethnicity were not collected from any participant.
Body weight	88.5 kg n=38 Participants	88.3 kg n=140 Participants	88.4 kg n=178 Participants
Body mass index	28.7 kg/m² n=38 Participants	30.0 kg/m² n=140 Participants	29.7 kg/m² n=178 Participants
eGFR	50.3 mL/min/1.73m² n=38 Participants	55.9 mL/min/1.73m² n=140 Participants	54.7 mL/min/1.73m² n=178 Participants
HbA1c	7.8 % HbA1c n=38 Participants	7.7 % HbA1c n=140 Participants	7.7 % HbA1c n=178 Participants
Glucocorticoid use	3 Participants n=38 Participants	14 Participants n=140 Participants	17 Participants n=178 Participants
Home insulin total daily dose	36 units/day n=38 Participants	40 units/day n=140 Participants	40 units/day n=178 Participants
First blood glucose on presentation	207 mg/dL n=38 Participants	198 mg/dL n=140 Participants	200 mg/dL n=178 Participants

PRIMARY outcome

Timeframe: During the first 48 hours after admission

Population: All participants received at least the first dose by the calculator before clinicians adjusted their insulin doses

Participates developed blood glucose concentration lower than 54 mg/dL

Outcome measures

Outcome measures
Measure	Insulin Dosing Calculator n=38 Participants Participants received initial insulin doses by the calculator on hospital admission	Observational Cohort n=140 Participants Historical patients who received initial insulin doses by standard of care
Clinical Significant Hypoglycemia	0 Participants	1 Participants

SECONDARY outcome

Timeframe: During the first 24 hours after admission

Population: All participants received at least the first dose by the calculator before clinicians adjusted their insulin doses

Mean of all the point-of-care blood glucose readings during the first 24 hours after admission

Outcome measures

Outcome measures
Measure	Insulin Dosing Calculator n=38 Participants Participants received initial insulin doses by the calculator on hospital admission	Observational Cohort n=140 Participants Historical patients who received initial insulin doses by standard of care
Mean Blood Glucose Concentration (mg/dL)	184.5 mg/dL Standard Deviation 40.3	204.0 mg/dL Standard Deviation 63.4

SECONDARY outcome

Timeframe: During the first 48 hours after admission

Participates developed blood glucose concentration higher or equal to 300 mg/dL

Outcome measures

Outcome measures
Measure	Insulin Dosing Calculator n=38 Participants Participants received initial insulin doses by the calculator on hospital admission	Observational Cohort n=140 Participants Historical patients who received initial insulin doses by standard of care
Clinical Significant Hyperglycemia	1 Participants	42 Participants

SECONDARY outcome

Timeframe: During the first 48 hours after admission

Population: All participants received at least the first dose by the calculator before clinicians adjusted their insulin doses

Participates developed blood glucose concentration lower than 70 mg/dL

Outcome measures

Outcome measures
Measure	Insulin Dosing Calculator n=38 Participants Participants received initial insulin doses by the calculator on hospital admission	Observational Cohort n=140 Participants Historical patients who received initial insulin doses by standard of care
Hypoglycemia Lower Than 70 mg/dL	0 Participants	2 Participants

Adverse Events

Initial Insulin Dosing Calculator

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Observational Cohort

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Clinician researcher

University of Washington

Phone: 206-221-5705

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place