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Atalante Exoskeleton in the Rehabilitation of Patients With Amyotrophic Lateral Sclerosis

NCT06199284 · Status: SUSPENDED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-01-12

No results posted yet for this study

Summary

Using a MRI gait motor imagery paradigm in ALS patients in order to study how ALS affects the function of the central neural networks involved in gait function, we showed a reorganization of the motor networks that represents a compensatory response to the dysfunction of the networks involved in gait function. Our main hypothesis is that by providing coherent proprioceptive input to the sensorimotor integration areas, gait training with an exoskeleton may boost compensatory network reorganization and help to maintain function. We hypothesize that this can be achieved through a locomotion training strategy that reproduces normal gait motor patterns and appropriate sensory feedback. Gait training with an exoskeleton can meet these needs. The Atalante exoskeleton offers unique potential thanks to its cutting-edge technological features, hands-free functions and availability in numerous centers across Europe. Evaluation of its safety and efficacy in ALS is of the utmost interest in order to generalize this new approach in ALS.

Conditions

  • ALS - Amyotrophic Lateral Sclerosis

Interventions

DEVICE

Atalante exoskeleton

The gait training program using Atalante exoskeleton consisted of 3 sessions per week for 6 weeks. Each session includes the patient's installation and de-installation (10 min), walking training (30 min), and physical activities at the end of the session where the patient is in an upright position in the exoskeleton (e.g. badminton, boxing, or basketball) (5-10 min). For each participant, the assistance of the exoskeleton can be specifically adjusted and can be set symmetrically or asymmetrically bases on his capabilities.

Sponsors & Collaborators

  • Association pour la Recherche sur la Sclérose Latérale Amyotrophique et autres Maladies du Motoneurone

    collaborator UNKNOWN

  • Groupe Hospitalier Pitie-Salpetriere

    collaborator OTHER

  • Institut de Myologie, France

    collaborator OTHER

  • Station Debout

    collaborator UNKNOWN

  • Laboratory of Biomedical Imaging

    collaborator UNKNOWN

  • Institut de Recherche sur la Moelle épinière et l'Encéphale

    lead OTHER

Principal Investigators

  • Ghida TRAD, PhD · Sorbonne Université, Inserm, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), 75006-Paris (France), Neuromuscular Physiology and Evaluation Lab, Neuromuscular Investigation Center, Institute of Myology, 75013-Paris (France)

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-31
Primary Completion
2026-09-30
Completion
2027-01-29

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06199284 on ClinicalTrials.gov